Radiology:玩转DKI之利用DKI评价肝细胞肝癌微血管浸润的价值。

2017-10-06 shaosai MedSci原创

本研究旨在评价扩散峰度成像和传统磁共振(MR)成像结果(包括常规单b值扩散加权成像和形态学特点)在术前预测肝细胞肝癌(HCC)微血管浸润(MVI)的价值,并将结果发表在Radiology上。

本研究旨在评价扩散峰度成像和传统磁共振(MR)成像结果(包括常规单b值扩散加权成像和形态学特点)在术前预测肝细胞肝癌(HCC)微血管浸润(MVI)的价值,并将结果发表在Radiology上。

本研究共纳入了自2015年9月至2016年11月组织病理学结果证实的92处HCCs(40处MVI阳性病变和52处MVI阴性病变)的84例患者(中位年龄:54岁;范围29-79岁),并行术前MRI包括扩散峰度成像(b values: 0, 200, 500, 1000, 1500, and 2000 sec/mm 2),同时计算峰度、扩散率和表观扩散系数图。评价

传统MR图像中形态学特点。利用单变量和多变量Logistic回归分析评价以上参数作为MVI预测因子的价值。

结果为,在单变量分析中,与HCC MVI相关的特征为平均峰度值(P < .001)升高、平均扩散率(P = .033)和表观扩散系数(P = .011)减低、边界欠规则并有浸润(P = .005)、不均质环形强化(P = .026)。在多变量分析中,平均扩散峰度值(OR值为6.25; P = .001)、不均质环形强化(OR值为6.92; P = .046)是预测HCC中MVI的独立危险因子。平均扩散峰度值诊断HCC MVI的曲线下面积为0.784(最佳截断值为0.917).

本研究表明,平均峰度值升高结合不均质环形强化课作为HCC发生MVI的潜在预测生物标识物。

原始出处:

Wang WT, Yang L, Yang ZX , et al,Assessment of Microvascular Invasion of Hepatocellular Carcinoma with Diffusion Kurtosis Imaging. Radiology. 2017.DOI: 10.1148/radiol.2017170515

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    2018-09-21 xjy02
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    2017-10-08 mgqwxj
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    2017-10-08 huagfeg
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    2017-10-07 flysky120

    学习一下知识

    0

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    2017-10-06 天涯183

    非常好的文章.学习了

    0

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    2017-10-06 131****1460

    学习了受益匪浅

    0

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    2017-10-06 卡圣

    学习了.谢谢分享

    0

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