饥饿延长寿命?哦,也许不

2016-12-11 佚名 生物探索

之前多篇试验和研究试图证实,间歇性或者定期禁食有望延缓衰老、延长寿命。但是也有证据表明,适度热量限制不会延长寿命,相反这一举措甚至会缩短人类寿命。我们多认为端粒长度与人类衰老、寿命密切相关。它位于染色体末端,是一小段DNA-蛋白质复合体,有着负责维持染色体的完整性、调控细胞分裂周期的功能。随着染色体复制而逐渐缩短,一旦消耗殆尽,细胞将会立即激活凋亡机制走向死亡,所以端粒素有“生命时钟”之称。近期,

之前多篇试验和研究试图证实,间歇性或者定期禁食有望延缓衰老、延长寿命。但是也有证据表明,适度热量限制不会延长寿命,相反这一举措甚至会缩短人类寿命。

我们多认为端粒长度与人类衰老、寿命密切相关。它位于染色体末端,是一小段DNA-蛋白质复合体,有着负责维持染色体的完整性、调控细胞分裂周期的功能。随着染色体复制而逐渐缩短,一旦消耗殆尽,细胞将会立即激活凋亡机制走向死亡,所以端粒素有“生命时钟”之称。

近期,《The American Journal of Clinical Nutrition》期刊发表一篇文章表明,禁食或者饥饿会大大缩短男性后代的端粒长度,从而对他们的寿命产生影响。

这一研究由特拉维夫大学赛克勒医学院教授Eugene Kobyliansky、本•古里安大学物理治疗教授Leonid Kalichman和巴伊兰大学医学院教授David Karasik合作完成。

研究团队以在20世纪20年代初经历过大规模饥荒的人及其后代作为调研对象,评估了他们的端粒长度。他们居住在俄罗斯伏尔加中部地区的Chuvashia。早在1922年3月,该地区挨饿人群的比例达到90%,因为饥饿而死亡的人数达到30-50%。1923年4月情况开始好转,年底,人们终于熬过大饥荒时期。

研究团队发现:(1)相比于1922年之前出生的男性,1923年之后出生的男性白细胞端粒长变短了;(2)随后几代男性的端粒长度都很短;(3)饥荒对女性细胞端粒长短没有造成明显影响。

Kobyliansky表示:“这些研究成果仅仅只能表明,饥饿有可能会引发端粒缩短。”但是,相比于孩子的白细胞,饥饿对于成年人生殖细胞端粒长度的影响是否更为突出?饥饿引发的端粒缩短现象受性别影响?禁食是否会影响后代端粒长度?对于这些未知问题,研究人员表示还需要投入更多的试验。


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    2016-12-13 1e10c84am36(暂无匿称)

    是的,吃饱为好

    0

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    2016-12-13 lixh1719

    现在的问题是很多人的热量摄入超标

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=162484, encodeId=13091624845b, content=是的,吃饱为好, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Dec 13 14:00:33 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162375, encodeId=61af1623e5c9, content=现在的问题是很多人的热量摄入超标, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Tue Dec 13 08:23:25 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454734, encodeId=ed901454e346f, content=<a href='/topic/show?id=d370101185d7' target=_blank style='color:#2F92EE;'>#饥饿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101185, encryptionId=d370101185d7, topicName=饥饿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c9a5593064, createdName=guojianrong, createdTime=Tue Dec 13 01:34:00 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479845, encodeId=01f514e98458a, content=<a href='/topic/show?id=456b4954350' target=_blank style='color:#2F92EE;'>#延长寿命#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49543, encryptionId=456b4954350, topicName=延长寿命)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d9587588723, createdName=hittouch, createdTime=Tue Dec 13 01:34:00 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162136, encodeId=d10a1621360a, content=很新颖的文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76491981781, createdName=1e184d7bm65(暂无匿称), createdTime=Mon Dec 12 09:28:40 CST 2016, time=2016-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=161992, encodeId=5e3716199216, content=被动的挨饿和主动的热量限制完全不是一回事吧。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJlA3ibO4ekS0GXIH3vkCI9YYRZnN9zDhA6EpRRUF4kg6E45xjReQWsIRhWxVpNgLQKqUPG9rAzp4A/0, createdBy=da761604631, createdName=kantwrite, createdTime=Sun Dec 11 16:52:44 CST 2016, time=2016-12-11, status=1, ipAttribution=)]
    2016-12-12 1e184d7bm65(暂无匿称)

    很新颖的文章!

    0

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    2016-12-11 kantwrite

    被动的挨饿和主动的热量限制完全不是一回事吧。。。

    0

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