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胃旁路术与胆胰转流术均能较好控制糖尿病大鼠血糖水平

2012-04-09 小哲 摘编 医学论坛网

2型糖尿病胃旁路术胆胰转流术
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　　日前，上海交通大学附属上海第六人民医院普外科狄建忠、韩晓东、张宏玮等人共同发表论文，旨在比较胃旁路术(GBP)与胆胰转流术(BPD)对非胰岛素依赖性糖尿病大鼠的治疗效果，探讨其机制。研究指出，GBP和BPD均能较好地控制糖尿病大鼠的血糖水平，其机制可能与瘦素的降低及IGF-1的升高有关。GBP在手术时间、死亡率及增加血IGF-1水平等方面优于BPD。该文发表在2011年第11卷第5期《中华胰腺

　　日前，上海交通大学附属上海第六人民医院普外科狄建忠、韩晓东、张宏玮等人共同发表论文，旨在比较胃旁路术(GBP)与胆胰转流术(BPD)对非胰岛素依赖性糖尿病大鼠的治疗效果，探讨其机制。研究指出，GBP和BPD均能较好地控制糖尿病大鼠的血糖水平，其机制可能与瘦素的降低及IGF-1的升高有关。GBP在手术时间、死亡率及增加血IGF-1水平等方面优于BPD。该文发表在2011年第11卷第5期《中华胰腺病杂志》上。

　　40只糖尿病GK大鼠按数字表法随机分为GBP组、BPD组、饮食控制组和对照组，每组10只。GBP组、BPD组分别行GBP及BPD手术；饮食控制组大鼠每天给予基础饲料15 g，自由进水；对照组不限食量。记录手术时间、死亡率。每周测空腹体重。检测治疗前及治疗后1、2、3、4、8、16周的空腹血糖、瘦素、胰岛素样生长因子-1(IGF-1)水平。

　　结果GBP组平均手术时间为(25±4)min，BPD组为(35±6)min；GBP组大鼠死亡1只，BPD组死亡3只，两组差异均有统计学意义。治疗前各组大鼠血糖、瘦素及IGF-1水平无统计学差异。治疗后对照组大鼠血糖及瘦素均无明显变化。饮食控制组大鼠治疗后2周起血糖及瘦素水平开始下降，第4周时显著降低，并持续至16周，但血IGF-1水平无明显变化。GBP组与BPD组大鼠治疗后2周起血糖及瘦素水平开始下降，而血IGF-1水平开始升高，并持续至16周，但这两组的血糖及瘦素水平无统计学差异；而GBP组大鼠血IGF-1水平较BPD组升高更显著。

　　相关链接：胃旁路术与胆胰转流术治疗2型糖尿病机制的研究



    

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    2012-09-15 lsj628

    #血糖水平#

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    2013-01-14 654699882_84926986

    #转流术#

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    2012-11-12 zhzhxiang

    #胃旁路术#

    0

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    2012-09-17 limedical1974

    #胃旁路#

    0

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    2013-03-22 more is better!

    #胆胰转流术#

    0

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