AP&T:肌肉减少症与慢性乙肝的代谢不良受的患者中肝纤维化的风险增加相关

2018-08-30 MedSci MedSci原创

肌肉减少症与肝纤维化程度显着相关。本研究调查了肌肉减少症对慢性乙型肝炎患者肝纤维化的影响。

背景
肌肉减少症与肝纤维化程度显着相关。本研究调查了肌肉减少症对慢性乙型肝炎患者肝纤维化的影响。

方法
研究人员分析了2008 - 2011年韩国国家健康和营养检查调查的数据。使用双能X射线吸收测定法计算肌肉减少症指数(骨骼肌质量[kg] /体重指数[kg / m2])。肌肉减少症被定义为最低的五分位度肌肉减少症指数值(截止值:男性为0.89,女性为0.58)。使用非酒精性脂肪肝疾病纤维化评分评估纤维化程度。显着纤维化被定义为最高的非酒精性脂肪肝疾病纤维化评分四分位数和纤维化-4指数≥2.67。

结果
在506名慢性乙型肝炎患者(258名男性和248名女性)中,非酒精性脂肪性肝病纤维化评分和纤维化-4指数>2.67的患者有126例(24.9%)和217例(42.9%)。无论使用何种纤维化预测模型,肌肉减少症与显着的肝gan纤维化存在显着相关性(P<0.05)。当根据代谢因素对研究人群进行分层时,肌肉减少症与肥胖,胰岛素抵抗,代谢综合征和肝脂肪变性亚组之间的显着纤维化风险增加特异性相关(OR: 2.37-3.57; P<0.05)。在调整其他混杂因素后,肌肉减少症和肝纤维化之间的独立关联(P<0.05)。

结论
肌肉减少症与慢性乙型肝炎患者的显着肝纤维化有关,特别是那些患有肥胖症,胰岛素抵抗,代谢综合征和肝脏脂肪变性的患者这个相关性更加明显。

原始出处:

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    2018-08-31 太阳系小猪

    现在人普遍肥胖加肌肉少,有肌肉的基本上是些健身爱好者和健身达人,要运动起来了!

    0

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    2018-08-30 13718711b3m

    非常不错的临床经验,值得借鉴,学习了,受益匪浅,谢谢分享!

    0

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