Int J Med Sci:人角膜内皮祖细胞的特征与展望!

2017-08-27 cuiguizhong MedSci原创

昆明市燕安医院眼科的Liu Y近日在 Int J Med Sci杂志发表了一篇文章,题目为"Characterization and Prospective of Human Corneal Endothelial Progenitors" ,系统性的论述了角膜组织工程的研究现状,并对人角膜内皮细胞重编程成其祖细胞的方法和其特征进行了论述,对人角膜内皮祖细胞的增殖方法和以及它们作为角膜内皮细胞移植

昆明市燕安医院眼科的Liu Y近日在 Int J Med Sci杂志发表了一篇文章,题目为"Characterization and Prospective of Human Corneal Endothelial Progenitors" ,系统性的论述了角膜组织工程的研究现状,并对人角膜内皮细胞重编程成其祖细胞的方法和其特征进行了论述,对人角膜内皮祖细胞的增殖方法和以及它们作为角膜内皮细胞移植物的潜在临床应用的最新进展也进行了讨论。

角膜功能障碍可导致角膜水肿和失明等严重影响。角膜内皮细胞在维持角膜透明度和由于衰老、疾病(如Fuch's营养不良)、损伤或手术创伤等引起的功能障碍等方面发挥关键作用。由于角膜内皮细胞体内增殖能力有限,因此,唯一的治疗方法是通过移植供体角膜。 然而,全球角膜供应短缺严重。

为了规避这些问题,随着近期这一领域的研究逐步深入,角膜组织的组织工程是一个可行的方案。作者在本综述中,总结了将成人角膜内皮细胞重编程成其祖细胞的方法,并对人角膜内皮祖细胞特征进行了论述,对人角膜内皮祖细胞的增殖方法和以及它们作为角膜内皮细胞移植物的潜在临床应用的最新进展也进行了讨论。这项工作大大加深了眼科临床医生对角膜移植的认识,并给诸多等待角膜移植的患者带来了希望。

原文出处:

Liu, Y., et al., Characterization and Prospective of Human Corneal Endothelial Progenitors. Int J Med Sci, 2017. 14(8): p. 705-710.

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    2017-08-29 snowpeakxu
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    2017-08-27 184****9840

    学习了谢谢分享

    0

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    2017-08-27 中医痴

    不错的.学习了.谢谢分享!

    0