性激素与老年女性慢性骨骼肌肉痛相关

2016-03-24 佚名 睿医

根据最近在线发表于《疼痛》杂志上的一项荷兰研究,性激素水平降低与社区老年女性慢性肌肉骨骼痛风险增加相关。 研究人员表示,相较于男性,慢性疼痛在女性人群中更加普遍。而且这种差异会随着年龄增加而变大。尤其对女性而言,随时间推移性激素的变化可影响疼痛敏感性。 为进一步探究性激素与慢性疼痛的相关性,研究人员对超过5500名女性和超过4200名男性数据进行分析(平均年龄,

根据最近在线发表于《疼痛》杂志上的一项荷兰研究,性激素水平降低与社区老年女性慢性肌肉骨骼痛风险增加相关。

研究人员表示,相较于男性,慢性疼痛在女性人群中更加普遍。而且这种差异会随着年龄增加而变大。尤其对女性而言,随时间推移性激素的变化可影响疼痛敏感性。

为进一步探究性激素与慢性疼痛的相关性,研究人员对超过5500名女性和超过4200名男性数据进行分析(平均年龄,65岁)。

62%的女性和45%的男性伴有至少三个月的后背、双手、膝盖和/或臀部的慢性疼痛。

研究人员对性激素(包括雌激素、睾酮、雄烯二酮和17-羟孕酮)与慢性疼痛发病率和新发慢性疼痛的相关性进行探究发现,雄烯二酮水平最低组与慢性疼痛更频繁相关(OR 1.20)。雌激素水平最低更低的女性同样如此(OR 1.27)。

与17-羟孕酮水平最高的女性相比,17-羟孕酮水平最低女性新发慢性疼痛风险增加38%。

虽然慢性疼痛的老年男性雌二醇平均水平相对较低,但是研究人员并未在研究中发现男性慢性疼痛与性激素存在以上相一致的相关性。研究人员表示,激素影响的这种差异性反映了男性与女性人群慢性疼痛的病理生理学差异。这种机制差异仍需进一步研究。

研究人员同时指出,女性性激素水平低于慢性肌肉骨骼疼痛风险增加的这种相关性独立于生活方式及健康相关因素。

研究人员总结到,该研究表明性激素可能在慢性疼痛中发挥一定作用,患者出现慢性疼痛时,应考虑性激素问题。性激素或许可成为慢性疼痛的一项潜在治疗目标。

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    2016-05-15 WEIXIN98222d2a

    我本人深有体会!

    0

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    2016-04-22 1dea6088m20(暂无匿称)

    老年女性骨骼肌痛极其常见有时没有什么损伤也发生与雌激素缺失有关推理有这种可能两者平行存在要进行雌激素测定扩大人群基数个体患者性激素数值与痛的频度严重性联系研究及个体痛耐受性感知差别与性激素存在联系否

    0

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    2016-03-27 1de8c9efm46(暂无匿称)

    看到好的,也得看看其他副作用

    0

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    2016-03-24 Lisa971

    老人对疼痛的抗受能力更弱?

    0

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