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JAMA：粉样蛋白（A）、tau蛋白（T）和神经变性生物标志物与记忆下降

2019-06-19 MedSci MedSci原创

粉样蛋白tau蛋白神经变性生物标志物
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研究认为，对于基线无痴呆的老年人中，淀粉样PET、tau PET和MRI皮质厚度综合应用在预测记忆衰退方面极具统计学意义

目前，阿尔茨海默病相关的生物标记包括淀粉样蛋白（A）、tau蛋白（T）和神经变性生物标志物（N）。近日研究人员考察了60岁或60岁以上无痴呆的人群中AT(N)生物标志物谱与记忆力下降之间的关系。

480例老年参与者，参与者接受临床评价和淀粉样蛋白正电子发射断层扫描（PET-A）、TAUPET（T）和磁共振成像（MRI）皮质厚度（N）测量，结果包括A、T或N都可以是异常(+)或正常(+)，总计8个亚组。研究的主要结局是15个月为间隔纵向复合记忆评分。

平均随访4.8年，44%为女性（211/480）。年龄范围从A-T-（N）-组的67岁到A+T+（N）+组的83岁。在受试者中，92%（441/480）认知功能未受损，但A+T+（N）+组轻度认知功能受损的比例最大（30%）。与其他5个AT（N）组相比，A+T+（N）+、A+T+（N）-和A+T-（N）+组的记忆下降最快。对于85岁的APOEε4非携带者，记忆下降率z评分分别为每年-0.13、-0.10及-0.10。

研究认为，对于基线无痴呆的老年人中，淀粉样PET、tau PET和MRI皮质厚度综合应用在预测记忆衰退方面极具统计学意义。

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    2020-02-14 hukaixun

    #标志物#

    0

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    2019-06-21 huangdf

    #变性#

    0

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    2019-06-21 szhvet

    #Tau#

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    2019-06-21 zhu_jun9842

    #生物标志#

    0

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    2019-06-21 zhu_jun9842

    #生物标志#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1841399, encodeId=5e4418413993e, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Feb 14 21:45:00 CST 2020, time=2020-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463682, encodeId=58c014636820f, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Fri Jun 21 09:45:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1509278, encodeId=9fbf15092e814, content=<a href='/topic/show?id=19791e14471' target=_blank style='color:#2F92EE;'>#Tau#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17144, encryptionId=19791e14471, topicName=Tau)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55c610090940, createdName=szhvet, createdTime=Fri Jun 21 09:45:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560831, encodeId=590315608317b, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Jun 21 09:45:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566840, encodeId=226215668404f, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Fri Jun 21 09:45:00 CST 2019, time=2019-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590523, encodeId=16e71590523d0, content=<a href='/topic/show?id=d785e42454f' target=_blank style='color:#2F92EE;'>#神经变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74245, encryptionId=d785e42454f, topicName=神经变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d72417807199, createdName=mfx805, createdTime=Fri Jun 21 09:45:00 CST 2019, time=2019-06-21, status=1, ipAttribution=)]
    2019-06-21 mfx805

    #神经变性#

    0