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Am J Clin Nutr:B族维生素或n-3脂肪酸不能改善心脏病幸存者抑郁

2012-08-01 不详 网络

B族维生素n-3脂肪酸心脏病幸存者抑郁
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SU.FOL.OM3(补充叶酸、维生素B-6和B-12和/或ω-3脂肪酸试验)是一项二级预防试验，于2003~2009年间纳入2,501例年龄45~80岁的受试者。将受试者随机分组，给予5-甲基四氢叶酸(0.56 mg)、维生素B6(3 mg)和B12(0.02 mg)；以2:1比例给予EPA和DHA(600 mg)；给予B族维生素和n-3脂肪酸；或给予安慰剂。在第3年和第5年时用GDS老年抑郁量

SU.FOL.OM3(补充叶酸、维生素B-6和B-12和/或ω-3脂肪酸试验)是一项二级预防试验，于2003~2009年间纳入2,501例年龄45~80岁的受试者。将受试者随机分组，给予5-甲基四氢叶酸(0.56 mg)、维生素B6(3 mg)和B12(0.02 mg)；以2:1比例给予EPA和DHA(600 mg)；给予B族维生素和n-3脂肪酸；或给予安慰剂。在第3年和第5年时用GDS老年抑郁量表评估抑郁症状。

结果显示，经过中位时间4.7年的干预，补充B族维生素与抑郁症状无关。然而，男性补充n-3脂肪酸与抑郁症状(GDS＞10)呈正相关(校正OR值，1.28; 95%CI，1.03~1.61)，女性中则不存在这种效应

研究者总结认为，长期、小剂量补充B族维生素或n-3脂肪酸对心血管疾病幸存者的抑郁症状没有益处。n-3脂肪酸对男性健康似有不良影响。

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    2012-10-17 mhzhuang@stu.e

    #3脂肪酸#

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    2013-02-09 mhzhuang@stu.e

    #3脂肪酸#

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    2012-08-03 ms1692212821629096

    #B族维生素#

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