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Redox Biol：肝脏缺血再灌注损伤与IDH2功能损伤有关

2017-09-26 Emma MedSci原创

肝脏缺血线粒体氧化应激细胞凋亡IDH2
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肝缺血再灌注（HIR）损伤是指受损伤的肝组织恢复血液供应后，不利于缺血的组织、器官的功能的恢复，甚至加重了肝脏代谢的障碍、结构的破坏。

肝缺血再灌注（HIR）损伤是指受损伤的肝组织恢复血液供应后，不利于缺血的组织、器官的功能的恢复，甚至加重了肝脏代谢的障碍、结构的破坏。过量的自由基会攻击重新获得血液供应的组织，造成损伤。IDH2（线粒体NADP +依赖性异柠檬酸脱氢酶2）是NADPH的主要生产者，需要包括谷胱甘肽过氧化物酶（GPx）和谷胱甘肽还原酶（GR）在内的谷胱甘肽（GSH）相关线粒体抗氧化系统正常运转。

研究人员使用同窝出生的Idh2敲除（Idh2 -/-）小鼠和野生型（Idh2 +/+）小鼠调查IDH2在肝缺血再灌注（HIR）中的作用。结果显示，HIR损害IDH2-NADPH-GSH线粒体抗氧化系统，导致线粒体氧化损伤以及功能障碍增加，此外，IDH2在线粒体氧化还原平衡中发挥关键作用，HIR引起的IDH2功能损伤与缺血再灌注诱导的肝衰竭发病机制有关。

研究人员对小鼠进行60分钟的局部肝缺血手术，试验组给予mito-TEMPO（线粒体靶向抗氧化剂）处理。HIR中Idh2 +/+小鼠和Idh2 -/-小鼠肝脏均出现严重组织学和功能损伤，而Idh2 -/-小鼠的损伤比野生型更严重。HIR诱导IDH2功能障碍，使NADPH水平、线粒体GR、GPx功能降低，导致线粒体和细胞氧化损伤，如线粒体嵴损失、线粒体碎裂、线粒体裂隙移位、细胞色素c释放和细胞死亡，HIR诱导的以上变化在Idh2-/-小鼠中更严重。Mito-TEMPO补充剂能够显著降低上述变化，并且对于Idh2 -/- 小鼠作用更明显。

原始出处：
Han SJ, et al. IDH2 deficiency increases the liver susceptibility to ischemia-reperfusion injury via increasedmitochondrial oxidative injury. Redox Biol. 2017 Sep 8;14:142-153. doi: 10.1016/j.redox.2017.09.003.

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    2017-11-08 JR19860219

    #肝脏缺血#

    0

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    2018-02-24 snf701207

    #IDH2#

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    2017-10-19 ms9833124466084992

    #再灌注损伤#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1808398, encodeId=466b1808398c4, content=<a href='/topic/show?id=6e6d814669c' target=_blank style='color:#2F92EE;'>#肝脏缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81466, encryptionId=6e6d814669c, topicName=肝脏缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Wed Nov 08 02:01:00 CST 2017, time=2017-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003320, encodeId=55ce200332027, content=<a href='/topic/show?id=944c94215e' target=_blank style='color:#2F92EE;'>#IDH2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9421, encryptionId=944c94215e, topicName=IDH2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Sat Feb 24 13:01:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763586, encodeId=696f1e63586ff, content=<a href='/topic/show?id=8c323064e09' target=_blank style='color:#2F92EE;'>#再灌注损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30647, encryptionId=8c323064e09, topicName=再灌注损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=56da37541085, createdName=ms9833124466084992, createdTime=Thu Oct 19 00:01:00 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917682, encodeId=d952191e682bc, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jun 16 07:01:00 CST 2018, time=2018-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=271039, encodeId=92712e1039d9, content=好资料学习了好资料!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Dec 20 23:35:34 CST 2017, time=2017-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767242, encodeId=601c1e672420f, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Sun Sep 02 04:01:00 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256340, encodeId=d93a256340fb, content=线粒体.抗氧化.基因敲除.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=acef1528050, createdName=501522391, createdTime=Fri Oct 27 09:01:57 CST 2017, time=2017-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397333, encodeId=9017139e3334f, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu Sep 28 01:01:00 CST 2017, time=2017-09-28, status=1, ipAttribution=)]
    2018-06-16 sunylz

    #Bio#

    0

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    2017-12-20 虈亣靌

    好资料学习了好资料!

    0

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    2018-09-02 12498ebem31暂无昵称

    #Biol#

    0

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    2017-10-27 501522391

    线粒体.抗氧化.基因敲除.学习了

    0

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    2017-09-28 ms3046638856685384

    #损伤#

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