肿瘤防治应符合人体内在的发展规律

2017-10-23 左占杰 人民政协网

2015年全国肿瘤登记结果显示,我国癌症新发病例429.2万例,死亡人数281.4万人,这一数据意味着,我国每分钟就有8.3人患癌症,5.2人死于癌症。癌症已成为我国面临的重大公共卫生问题之一。今年10月9日的国务院常务会议明确提出“要集中优势力量开展疑难高发癌症治疗专项重点攻关”。医学技术越来越进步,医生队伍越来越庞大,而肿瘤病人却越来越多,晚期肿瘤仍然治疗效果不佳。据了解,美国FDA正式批准肿

2015年全国肿瘤登记结果显示,我国癌症新发病例429.2万例,死亡人数281.4万人,这一数据意味着,我国每分钟就有8.3人患癌症,5.2人死于癌症。癌症已成为我国面临的重大公共卫生问题之一。今年10月9日的国务院常务会议明确提出“要集中优势力量开展疑难高发癌症治疗专项重点攻关”。医学技术越来越进步,医生队伍越来越庞大,而肿瘤病人却越来越多,晚期肿瘤仍然治疗效果不佳。据了解,美国FDA正式批准肿瘤生物治疗药物Provenge上市,针对512名前列腺癌病人的追踪研究发现,该药物只能延长病人4.1个月的生存寿命,但却需要付出30万美元、3个疗程的高昂代价。2013年美国FDA自曝批准上市的抗癌药物75%无效;美国癌症研究所专家评价2009年以来批准的83个抗癌药物效果差强人意。

基因与疾病的相关性可能存在误区

科学发展到今天,对于人体存在的基因暗物质,从遗传密码来讲,人类并不知道97%的遗传密码的作用是什么。现代临床医院检测肿瘤的指标只占3%,剩余97%与疾病相关的东西根本没有融入到诊断治疗的视野当中,这就是疾病治疗效果一直徘徊不前的根本原因。国际著名期刊《细胞》刊文呼吁,科学家应当重新审视基因组相关性研究(GWAS)项目。越来越多的确凿证据表明,从多基因到全基因测序来认知疾病的意义并不大,所谓基因与疾病的相关性可能是一个误区。

现代医学认为肿瘤细胞来自于正常细胞,癌变是一个多阶段的发展过程,从正常细胞到癌之间有一个癌前病变阶段。从癌前病变发展成癌是一个缓慢的过程,癌变过程的长短不仅取决于癌变部位、致癌因素的强弱,而且与个体易感性及免疫功能相关。分析近年来大规模的人类肿瘤基因研究资料,提示肿瘤的发生、发展可能不是相关基因异常改变的叠加作用的结果,而是细胞生长、分化等通路基因群网络系统功能异常,驱动正常细胞向癌细胞发展。可以认为肿瘤是一种细胞增殖及分化异常的分子网络病。在同一个体的原发与转移肿瘤之间,甚至同一个体同一肿瘤内不同细胞之间,基因突变差异亦相当大。而同一肿瘤不同部位的组织还可以呈现出预后良好和不好的基因表达特征。据最近的相关研究表明,癌前病变的另一个特点是有一定的可逆性,许多癌前病变是会消退的。宿主因素对肿瘤发生、发展有重要影响,这和宿主的免疫系统参与有密切关系,研究癌前病变发生、发展过程中宿主因素的改变,对肿瘤早期防控具有重要意义。

潘德孚老中医曾把肿瘤发生比喻成河流溃堤,他认为因为出现河道溃堤而去研究水分子的结构,或者认为应该去研究那堵塞河道的泥沙,弄清它的组成成分是错误的,与我们治疗癌症研究癌细胞或癌基因一样,治理河流溃堤应该研究上游水土如何流失,天气、雨量、时间、河道宏观综合因素,而不是研究水分子(或泥沙)的组成结构。从逻辑推理来说,深入研究肿瘤细胞基因突变、代谢异常存在着一定的偏颇。人体生命包括三个系统,躯体系统、信息系统和意识系统,其中信息系统是躯体系统与意识系统的中枢,也是生命的关键和根本。意识系统是在躯体系统与信息系统的基础上形成的可自控系统,通过意识的自控,可以使信息系统的自组织力加强并有序,从而逆转躯体系统的疾病而恢复健康。

医学应该是构建符合人体规律的艺术

只有理解了人体的神奇、奥妙,才能真正认识到医学的内涵和本质。生物体的生命过程复杂而又奇妙。人体是异常精密的仪器,我们体内的每一个细胞中都填充着数百甚至数千个这样的分子机器。DNA复制的错误率,通常小于1/109。按照功能医学理论认为,一切人体现象都是正常细胞对外界不良环境的适应,长期持续不良环境刺激,产生机体功能代谢失衡,导致机体异常代谢,代谢异常持续进展导致机体结构的改变,形成病理结构,结构的改变进一步影响机体的代谢,促进了肿瘤的增殖和转移,机体整体系统无法代偿代谢和结构的改变,导致生命现象消失。

医学应该是关于人协调发展躯体系统、信息系统和意识系统;身体、心理、灵魂三者之间和谐默契的一门医学艺术,涵盖了临床医学、哲学、艺术、宗教、心理、生命科学、环境、营养、人文科学、人工智能等学科构建的生态系统。在符合人体内在发展规律下,应用科学技术、方法提供全方位、全生命周期的监测和干预,最大限度地保持健康和最大程度地挽救生命。处理好人与自然的关系、人与人的关系,当然也就扩大到了人与社会的关系,还有人与自己内心的关系,圆满地处理好这三种关系。肿瘤防治应该按照生物自然发展规律,尽可能恢复身体的正常功能,通过整合医疗让机体恢复自愈力,恢复了生命的自组织能力才是肿瘤治愈的关键所在,而不是干预疾病表现出来的症状,更不是分成不同功能系统来分析疾病,身体或大脑的各个部分都会影响到整个生命系统中的其他部分。全系统模式像蜘蛛网一样,不同系统、器官之间形成错综复杂的联系,各个因素变化相互影响。全系统模式关注的是疾病过程中身体系统里具有相关性所有变化,而不仅仅关注具有因果关联的某种现象。

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    2017-10-23 欧阳星月dora

    学习.谢谢分享!!!有点和中医整体观念相似

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2083564, encodeId=3cf3208356479, content=<a href='/topic/show?id=a914e571429' target=_blank style='color:#2F92EE;'>#符合人体内在#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75714, encryptionId=a914e571429, topicName=符合人体内在)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Fri Feb 02 12:18:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971959, encodeId=d43619e19597e, content=<a href='/topic/show?id=4399831302f' target=_blank style='color:#2F92EE;'>#肿瘤防治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83130, encryptionId=4399831302f, topicName=肿瘤防治)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Tue Sep 18 13:18:00 CST 2018, time=2018-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1605066, encodeId=61cf1605066d5, content=<a href='/topic/show?id=66373e8504f' target=_blank style='color:#2F92EE;'>#发展规律#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37850, encryptionId=66373e8504f, topicName=发展规律)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2fd219313769, createdName=ms3117646317107274, createdTime=Wed Oct 25 00:18:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255425, encodeId=1723255425f5, content=学习.谢谢分享!!!有点和中医整体观念相似, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/be4YlKNv3rT6se8HUMWmAyS3eywXjKkf3TaeJkKrgAdTM1l1WesYwgkw2VAOVEWicdb6rCiaRbttqjb9ozpjCkGQ/0, createdBy=2d322139779, createdName=欧阳星月dora, createdTime=Mon Oct 23 21:26:50 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255314, encodeId=fc1225531411, content=多因素影响的观点是正确的.不过现在貌似都是线性分析., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210427/b594a756d77e4171b5313e531ef89b43/31c000a8a97d4872b698c80fb8a33369.jpg, createdBy=624b2152505, createdName=大叔默默路过, createdTime=Mon Oct 23 09:32:58 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2017-10-23 大叔默默路过

    多因素影响的观点是正确的.不过现在貌似都是线性分析.

    0

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