Semin Arthritis Rheu:无症状高尿酸血症患者OMERACT定义的痛风基本超声病变的患病率和辨别度

2019-01-15 xiangting MedSci原创

在无症状高尿酸血症人群中,1MTP和股骨髁双轮廓以及1MTP痛风石患病率最高,并可以与尿酸正常的人进行区分。

已经对无症状高尿酸血症的痛风超声损伤进行了描述。然而,无症状高尿酸血症最常累及的解剖部位和超声病变尚不清楚。这项系统评价和荟萃分析旨在确定无症状高尿酸血症患者不同部位风湿病结果测量(OMERACT)痛风基本超声病变(双轮廓、聚集物、痛风石、糜烂)的患病率,并确定哪些部位和病变可以与尿酸正常的人进行区分。

研究人员系统检索了电子数据库、会议摘要和参考文献清单。如果对无症状高尿酸血症患者进行超声成像并报告了≥1个OMERACT定义的痛风病变,则纳入该研究。对无症状高尿酸血症患者的部位特异性病变的汇总患病率进行Meta分析,并将这些病变的汇总比值比与尿酸正常的人进行比较。

纳入了20项研究。扫描的最常见部位是第一跖趾关节(1MTP)(n=17项研究),报告的最常见病变是双轮廓(n=18)。汇总患病率的meta分析显示1MTP双轮廓是无症状高尿酸血症患者中最常见的发现(0.31,95%可信区间(CI)0.20-0.42),其次是股骨髁双轮廓(0.16,95%CI 0.08-0.24)和1MTP痛风石(0.16,95%CI 0.03-0.29)。对于1MTP双轮廓,无症状高尿酸血症vs.尿酸正常的最高汇总比值比为6.98(95%CI 3.14-15.57),股骨髁双轮廓为13.67(95%CI 5.42-34.49),1MTP痛风石为6.10(95%CI 1.55-24.04)。

在无症状高尿酸血症人群中,1MTP和股骨髁双轮廓以及1MTP痛风石患病率最高,并可以与尿酸正常的人进行区分。

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    2019-01-17 zhaojie88
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