Gastroenterology:精神状态,内脏超敏反应和异常结肠转运均对肠易激综合征起到了诱导作用

2019-07-26 不详 MedSci原创

关于病理生理因素与肠易激综合征(IBS)症状之间的联系目前还没有报道,本项研究探究了与IBS相关的病理生理改变是否对疾病发生具有累积或独立影响。

背景与目的
关于病理生理因素与肠易激综合征(IBS)症状之间的联系目前还没有报道,本项研究探究了与IBS相关的病理生理改变是否对疾病发生具有累积或独立影响。

方法
研究人员对IBS患者(n = 407; 74%女性;平均年龄36±12岁)的数据进行了回顾性分析。所有患者都接受了结肠通过时间的评估; 顺应性,异常性疼痛和痛觉过敏(直肠恒压)评估; 焦虑和抑郁(医院焦虑和抑郁量表)评估。功能障碍由可用的正常值定义。

结果
36%的患者出现异常性疼痛,22%的患者出现痛觉过敏,18%的结肠转运加速,7%的转运延迟,52%的患者存在焦虑和24%的患者存在抑郁。直肠顺应性与更严重的IBS症状无关。20%的患者至少有3种病理生理因素,30%中有2种,31%中有1种,18%中没有。随着病理生理异常的增加,IBS症状严重程度(P <.0001)和躯体症状严重程度(P  <.0001)逐渐增加,生活质量逐渐下降(P <.0001)。

结论
内脏超敏反应,包括异常性疼痛和痛觉过敏,异常结肠转运和心理因素都与IBS症状有关。这些因素对IBS患者的肠道和非肠道症状以及生活质量具有累积效应。

原始出处:

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    2019-11-22 许安
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    2020-03-24 yzh409
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    2020-01-28 jyzxjiangqin

    精神疾病的治疗。

    0

  6. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=2072646, encodeId=e4b220e26467b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Nov 22 04:03:00 CST 2019, time=2019-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696341, encodeId=75ef1696341cc, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, 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GetPortalCommentsPageByObjectIdResponse(id=370369, encodeId=2f523e0369ca, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Jul 27 22:17:26 CST 2019, time=2019-07-27, status=1, ipAttribution=)]
  9. 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GetPortalCommentsPageByObjectIdResponse(id=370369, encodeId=2f523e0369ca, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Jul 27 22:17:26 CST 2019, time=2019-07-27, status=1, ipAttribution=)]
    2019-07-28 泥潭里的虾米

    原始出处是全英文

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=370369, encodeId=2f523e0369ca, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Jul 27 22:17:26 CST 2019, time=2019-07-27, status=1, ipAttribution=)]
    2019-07-27 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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