Diabetes Care:食用豆奶未影响2型糖尿病肾病炎症和氧化应激

2012-07-19 范伟伟 医学论坛网

     《糖尿病护理》(Diabetes Care)杂志2012年7月11日在线发表的一项随机、交叉对照临床试验研究表明:食用豆奶可降低2型糖尿病肾病患者血清中的D-二聚体水平。然而,患者的炎症和氧化应激标志物水平在食用豆奶后未发生显著性改变。   该研究目的在于评价与牛奶相比,豆奶的摄入对糖尿病肾病患者炎症、凝血功能和氧化应激是否产生影响。研究共纳入了25 例2型糖尿病

  豆奶

  《糖尿病护理》(Diabetes Care)杂志2012年7月11日在线发表的一项随机、交叉对照临床试验研究表明:食用豆奶可降低2型糖尿病肾病患者血清中的D-二聚体水平。然而,患者的炎症和氧化应激标志物水平在食用豆奶后未发生显著性改变。

  该研究目的在于评价与牛奶相比,豆奶的摄入对糖尿病肾病患者炎症、凝血功能和氧化应激是否产生影响。研究共纳入了25 例2型糖尿病肾病患者,随机分配接受添加豆奶或添加牛奶的饮食。采用交叉临床试验设计,每个研究组均经历两个试验阶段,包括4周的试验期和2周洗脱期。

  结果表明,食用豆奶可导致糖尿病肾病患者的D-二聚体水平显著降低(百分率变化:-3.77%对16.13%,P <0.05)。即使在校正混杂因素(碳水化合物的摄入量)后,该显著性仍然存在。但是,食用豆奶对糖尿病肾病患者的肿瘤坏死因子-α,白细胞介素-6,高敏C-反应蛋白(hs-CRP)和丙二醛的表达水平均没有显著性影响。食用豆奶对hs-CRP水平的影响接近统计学显著性(百分比变化:-35.45%和36.76%,P=0.05),但是,该显著性在校正混杂变量(碳水化合物的摄入量)后消失。

  链接:Maryam Sadat Miraghajani, MSC1,2, Ahmad Esmaillzadeh, PHD1,2,Mojgan Mortazavi Najafabadi, MD3, Maryam Mirlohi, PHD1,4 and Leila Azadbakht, PHD1,2⇓.Soy Milk Consumption, Inflammation, Coagulation, and Oxidative Stress Among Type 2 Diabetic Patients With Nephropathy.Diabetes Care



    

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