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Int J Impot Res：无针头注射设备海绵疗法的应用

2017-07-30 AlexYang MedSci原创

阴茎勃起功能障碍无针头注射疗法
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阴茎勃起功能障碍（ED）在男性群体中占据着显著的比例。随着男性群体年龄的增长，ED的流行程度在下一个十年预计会加倍。口服PDE-5抑制剂是治疗ED首选的治疗方法，并且在ED治疗方面起到了关键性的作用。然而，这些药物在一些男性中却表现出治疗效果不佳的情况。阴茎注射（ICI）作用于血管的药物是治疗ED次选的治疗有效方法。尽管被证明是有效的，打针恐惧症和焦虑限制了海绵体（IC）疗法的应用。然而，无针头注

阴茎勃起功能障碍（ED）在男性群体中占据着显著的比例。随着男性群体年龄的增长，ED的流行程度在下一个十年预计会加倍。口服PDE-5抑制剂是治疗ED首选的治疗方法，并且在ED治疗方面起到了关键性的作用。然而，这些药物在一些男性中却表现出治疗效果不佳的情况。

阴茎注射（ICI）作用于血管的药物是治疗ED次选的治疗有效方法。尽管被证明是有效的，打针恐惧症和焦虑限制了海绵体（IC）疗法的应用。然而，无针头注射的（NFI）设备可以让注射类药物通过皮肤，而不是针头来进行体内扩散治疗。尽管这些设备已经普及了几十年，早期关于调查它们在ICI中的使用的研究表明它们的效果和标准的针尖注射扩散比较起来并不理想。另外，最近这些系统的工程学进展导致了许多液体传播因素的功能改善。

最近，有研究人员的研究阐释了现代NFI设备能够更好的传播ICI，并且在尸体模型上的检验表明了可以获得成功的IC扩散。研究人员还指出，这些发现支持了NFI设备潜在的扩散ICI的可能性，并且也许能够扩展这些设备的的应用，特别是那些因为打针恐惧症或者标准针尖注射其他相关问题而拒绝或者停止IC治疗的病人中，该设备最容易获得他们的认可。

原始出处：

D O'Kane， L Gibson， J du Plessis et al. Delivery of intracavernosal therapies using needle-free injection devices. Int J Impot Res. 27 July 2017.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1575066, encodeId=e00815e5066fb, content=<a href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Mon Jul 31 15:00:00 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228421, encodeId=7d912284218f, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Jul 31 09:26:08 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228413, encodeId=493022841306, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Mon Jul 31 09:23:34 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228381, encodeId=7832228381d1, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Mon Jul 31 09:07:55 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228355, encodeId=c46a228355b2, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Jul 31 08:05:31 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228350, encodeId=0a2f22835085, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon Jul 31 07:59:42 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 风铃826

    #MPO#

    0

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    2017-07-31 明月清辉

    谢谢分享，学习了

    0

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    2017-07-31 Y—xianghai

    学习了新知识

    0

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    2017-07-31 1e0e5a1fm42(暂无匿称)

    henhao

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1575066, encodeId=e00815e5066fb, content=<a href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Mon Jul 31 15:00:00 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228421, encodeId=7d912284218f, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Jul 31 09:26:08 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228413, encodeId=493022841306, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Mon Jul 31 09:23:34 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228381, encodeId=7832228381d1, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Mon Jul 31 09:07:55 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228355, encodeId=c46a228355b2, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Jul 31 08:05:31 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228350, encodeId=0a2f22835085, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Mon Jul 31 07:59:42 CST 2017, time=2017-07-31, status=1, ipAttribution=)]
    2017-07-31 龙胆草

    学习谢谢分享

    0

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    2017-07-31 执着追梦

    学习，谢谢分享

    0