JAMA Oncol:HPV测试对于非典型鳞状细胞妇女宫颈上皮内瘤样病变干预的影响

2017-06-23 zhangfan MedSci原创

研究认为进行人乳头状瘤病毒检测可更快更完整的发现宫颈疾病并及时进行治疗。高度宫颈上皮内瘤样病变患者其HPV阳性率为43.1%,急需相应的临床干预。该研究为宫颈癌筛查指南和公共卫生政策的制定提供了依据

目前对于高度宫颈上皮内瘤样病变(CIN)的长期结果以及细胞学检查显示未明确意义的非典型鳞状细胞分类的人乳头状瘤病毒(HPV)活检以及治疗率对疾病的影响尚不清楚。近日研究人员比较了在非典型鳞状细胞(ASC-US)分类后进行HPV检测以及不进行检测5年结果的差异。

在这项观察研究中,研究人员分析了2007年1月1日到2012年12月31日,新墨西哥所有妇女的宫颈细胞学和HPV检测报告。研究的主要目的是HPV检测对发病率、时间组织学证实的病变,活检或宫颈电环切除术率的影响。

研究包含457317名妇女,平均年龄39.8岁,其20677名(4.5%)妇女检测证实ASC-US,其中进行HPV检测的妇女其III度以上CIN的比例为2.49%而不进行HPV检测妇女其III度以上CIN比例为2.15%,HPV测试使得组织学证实的病变时间更短(平均103天vs 393天)。HPV测试妇女CIN1I度的检出率为11.6%,不检测妇女为6.6% (rr,1.76;95% CI,1.56-2.00; P<0.001)。进行HPV检测的妇女其5年内进行电圈切除术比例提高20%且II-III级CIN比例更高。

研究认为进行人乳头状瘤病毒检测可更快更完整的发现宫颈疾病并及时进行治疗。高度宫颈上皮内瘤样病变患者其HPV阳性率为43.1%,急需相应的临床干预。该研究为宫颈癌筛查指南和公共卫生政策的制定提供了依据。

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    2017-09-09 minlingfeng
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    2017-06-28 jyzxjiangqin

    HPV测试对鳞状细胞的影响。

    0

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    2017-06-26 luominglian113

    学习了,谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1864971, encodeId=e83c18649e169, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Sep 09 16:12:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216208, encodeId=80f421620892, content=HPV测试对鳞状细胞的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jun 28 07:26:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215674, encodeId=ee0d2156e470, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jun 26 19:21:43 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215124, encodeId=f8862151242a, content=不错的方式,努力学习,刻苦专研,不断总结出来新经验。给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Jun 25 08:07:26 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408038, encodeId=9d5814080384e, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Sun Jun 25 07:12:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492593, encodeId=2a471492593d8, content=<a href='/topic/show?id=9b7c9929363' target=_blank style='color:#2F92EE;'>#非典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99293, encryptionId=9b7c9929363, topicName=非典型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bb98946820, createdName=sjzlzc010, createdTime=Sun Jun 25 07:12:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214526, encodeId=60f3214526b7, content=这个可以啊,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jun 23 23:48:17 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214420, encodeId=6b70214420b4, content=高度宫颈上皮内瘤样病变患者其HPV阳性率为43.1%,急需相应的临床干预。该研究为宫颈癌筛查指南和公共卫生政策的制定提供了依据。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Jun 23 16:35:22 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-25 ylzr123

    不错的方式,努力学习,刻苦专研,不断总结出来新经验。给点个赞!

    0

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    2017-06-25 一闲
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    2017-06-23 虈亣靌

    这个可以啊,不错

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1864971, encodeId=e83c18649e169, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sat Sep 09 16:12:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216208, encodeId=80f421620892, content=HPV测试对鳞状细胞的影响。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jun 28 07:26:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215674, encodeId=ee0d2156e470, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jun 26 19:21:43 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215124, encodeId=f8862151242a, content=不错的方式,努力学习,刻苦专研,不断总结出来新经验。给点个赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Jun 25 08:07:26 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408038, encodeId=9d5814080384e, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Sun Jun 25 07:12:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492593, encodeId=2a471492593d8, content=<a href='/topic/show?id=9b7c9929363' target=_blank style='color:#2F92EE;'>#非典型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99293, encryptionId=9b7c9929363, topicName=非典型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bb98946820, createdName=sjzlzc010, createdTime=Sun Jun 25 07:12:00 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214526, encodeId=60f3214526b7, content=这个可以啊,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jun 23 23:48:17 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214420, encodeId=6b70214420b4, content=高度宫颈上皮内瘤样病变患者其HPV阳性率为43.1%,急需相应的临床干预。该研究为宫颈癌筛查指南和公共卫生政策的制定提供了依据。, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Jun 23 16:35:22 CST 2017, time=2017-06-23, status=1, ipAttribution=)]
    2017-06-23 有备才能无患

    高度宫颈上皮内瘤样病变患者其HPV阳性率为43.1%,急需相应的临床干预。该研究为宫颈癌筛查指南和公共卫生政策的制定提供了依据。

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