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Int J Ophthalmol：通过逆转上皮间质转化miR-200c可抑制视网膜母细胞瘤的转移

2017-09-03 MedSci MedSci原创

视网膜母细胞瘤上皮间质转化miR-200c
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本研究旨在分析视网膜母细胞瘤（Rb）中上皮间质转化（EMT）与临床特征之间的关系，进一步探讨miR-200c是否调控EMT及Rb细胞的转移。采用免疫组织化学法检测29例RB组织中EMT相关标志物及肿瘤相关因子的表达。分析其表达与临床特征的关系。分别通过聚合酶链反应（PCR）和Western blot分析在mRNA水平和蛋白水平观察Y79 和WERI-RB1细胞中miR-200c对EMT相关标志物的

本研究旨在分析视网膜母细胞瘤（Rb）中上皮间质转化（EMT）与临床特征之间的关系，进一步探讨miR-200c是否调控EMT及Rb细胞的转移。

采用免疫组织化学法检测29例RB组织中EMT相关标志物及肿瘤相关因子的表达。分析其表达与临床特征的关系。分别通过聚合酶链反应（PCR）和Western blot分析在mRNA水平和蛋白水平观察Y79 和WERI-RB1细胞中miR-200c对EMT相关标志物的调节作用。同时使用Transwell测试检测对RB细胞迁移力的影响。

结果，在预后较差的患者中，E-钙黏着蛋白的表达较低。Y79 和WERI-RB1细胞中miR-200c促进E-钙黏着蛋白的表达并降低波形蛋白和N-钙黏着蛋白的表达。此外，miR-200c还可抑制Rb细胞的迁移力。

总之，该研究结果表明，EMT或与RB患者较差的预后相关。通过逆转EMT miR-200c可抑制RB细胞的迁移。

原始出处：

Xiao-Lei Shao, Yao Chen, Ling Gao. MiR-200c suppresses the migration of retinoblastoma cells by reversing epithelial mesenchymal transition. Int J Ophthalmol. 2017; 10(8): 1195–1202. Published online 2017 Aug 18. doi: 10.18240/ijo.2017.08.02.

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    2018-02-09 huperzia

    #母细胞瘤#

    0

  2. 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    2018-05-27 smallant2002

    #miR#

    0

  3. 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content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 03 23:29:58 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2018-01-21 limedical1984

    #上皮间质转化#

    0

  4. 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topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475845, encodeId=b67714e584574, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541277, encodeId=fb9115412e7c4, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240313, encodeId=541d24031342, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Mon Sep 04 08:49:14 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240206, encodeId=b0a92402068a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Sep 04 06:17:26 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240199, encodeId=f5a824019922, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 04 06:05:42 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240158, encodeId=e33d24015885, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 03 23:29:58 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-05 zutt

    #视网膜#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1772240, encodeId=89bf1e72240cc, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Fri Feb 09 22:59:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930508, encodeId=65141930508c6, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, 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objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240313, encodeId=541d24031342, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Mon Sep 04 08:49:14 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240206, encodeId=b0a92402068a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Sep 04 06:17:26 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240199, encodeId=f5a824019922, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 04 06:05:42 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240158, encodeId=e33d24015885, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 03 23:29:58 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-05 spoonycyy

    #细胞瘤#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1772240, encodeId=89bf1e72240cc, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Fri Feb 09 22:59:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930508, encodeId=65141930508c6, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Sun May 27 16:59:00 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704942, encodeId=b7771e0494231, content=<a href='/topic/show?id=7b3c20040c8' target=_blank style='color:#2F92EE;'>#上皮间质转化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20040, encryptionId=7b3c20040c8, topicName=上皮间质转化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd9530903442, createdName=limedical1984, createdTime=Sun Jan 21 14:59:00 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269944, encodeId=6ea81269944ba, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475845, encodeId=b67714e584574, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541277, encodeId=fb9115412e7c4, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240313, encodeId=541d24031342, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Mon Sep 04 08:49:14 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240206, encodeId=b0a92402068a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Sep 04 06:17:26 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240199, encodeId=f5a824019922, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 04 06:05:42 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240158, encodeId=e33d24015885, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 03 23:29:58 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-05 1249842em13(暂无昵称)

    #THA#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1772240, encodeId=89bf1e72240cc, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Fri Feb 09 22:59:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930508, encodeId=65141930508c6, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475845, encodeId=b67714e584574, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Tue Sep 05 11:59:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541277, encodeId=fb9115412e7c4, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, 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encodeId=b0a92402068a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Sep 04 06:17:26 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240199, encodeId=f5a824019922, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 04 06:05:42 CST 2017, time=2017-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240158, encodeId=e33d24015885, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 03 23:29:58 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-04 139****5926

    好好文章学习了

    0

  8. 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content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 03 23:29:58 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-04 130****4638

    学习了受益匪浅

    0

  9. 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content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 03 23:29:58 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-04 tanxingdoctor

    学习啦!谢谢分享!

    0

  10. 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content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun Sep 03 23:29:58 CST 2017, time=2017-09-03, status=1, ipAttribution=)]
    2017-09-03 luominglian113

    学习了.谢谢分享

    0

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发表在Cancer的一项新近研究针对青年时罹患视网膜母细胞瘤的民众进行了调查。 美国视网膜母细胞瘤患者的存活率非常高，5年存活率约为97%。然而,很少有人知道视网膜母细胞瘤患者未来的患病情况和幸福感。 由于既往关于视网膜母细胞瘤幸存者的晚年健康状况的相关研究样本量和范围有限，因此医务人员获得的相关知识非常有限。 纪念斯隆凯特林癌症中心的研究人员决定扩大样本量，以探究幸存者的生活质量及幸福感。视网膜

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视网膜母细胞瘤是一种来源于光感受器前体细胞的恶性肿瘤，是婴幼儿最常见的眼内恶性肿瘤，成人中罕见。具有家族遗传倾向，临床表现复杂，易发生颅内及远处转移，常危及患儿生命，早发现、早诊断及早治疗是提高治愈率、降低死亡率的关键。

Eur Radiol：晚期视网膜母细胞瘤在常规MRI结合扩散加权成像和组织病理学结果的相关性

在婴幼儿眼病中，是性质最严重、危害性最大的一种恶性肿瘤视网膜母细胞瘤(retinoblastoma，RB)是婴幼儿最常见的眼内恶性肿瘤，对视力和生命有严重的威胁和危害。发生于视网膜核层，具有家族遗传倾向，多发生于5岁以下，可单眼、双眼先后或同时罹患，本病易发生颅内及远处转移，常危及患儿生命，因此早期发现，早期诊断及早期治疗是提高治愈率、降低死亡率的关键。本研究为了验证常规MRI发现晚期眼内视网膜母