JAMA Dermat:体内反射共焦显微镜对黑色素瘤和黑色素斑唇的诊断

2017-05-04 zhangfan MedSci原创

反射共聚焦显微镜是有效的嘴唇良性黑色素斑点和唇黑色素瘤检测区分手段

良性黑色素斑点(MAC)是唇部色素沉着最常见的原因,但很难与唇黑色素瘤(MEL)区分。近日研究人员利用体内反射共聚焦显微镜(RCM)区分不同类型的正常的嘴唇并区分MAC与MEL的差异。

研究分别招募了2组2级中心转诊的患者,第一组为不同类型的正常的嘴唇者,第二组包含MAC与MEL患者,研究者对这2组患者进行皮肤镜和体内反射共聚焦显微镜检查。将RCM特征与临床病史,皮肤镜图像与组织病理学相关联。

研究对10名临床上正常的嘴唇(平均年龄34.5岁),16名MAC患者(平均年龄49.6岁)以及6名MEL患者中的5人进行了唇红唇和/或粘膜部分图像记录。对于MEL患者与MAC存在以下显著差异:表皮混乱、湿疹样浸润树突状细胞和/或圆细胞、真皮表皮交界处的非特异性的结构格局(DEJ)、非均匀乳头分布、DEJ特别是在间空间存在连续或斑点状明显异型性细胞增殖、高数量的树突状细胞(尤其是圆形的)以及DEJ典型的圆形细胞。MEL患者树突状细胞的细胞体面积约为MAC者的2倍。RCM唇检测对于MEL诊断表现出100%的敏感度以及88%的特异性。RCM联合皮肤镜将16例疑似患者中的13例归为良性,将6例疑似患者中的5例确诊为MEL。

研究表明反射共聚焦显微镜是有效的嘴唇良性黑色素斑点和唇黑色素瘤检测区分手段。

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