Rev Soc Bras Med Trop:在HTLV-1感染患者中,特应性反应和神经表现关系研究

2018-06-06 AlexYang MedSci原创

人类T淋巴细胞病毒类型1(HTLV-1)能够诱导过度的Th1响应,然而特应性反应与加剧的Th2响应相关。最近,有研究人员进行了一个代表性的研究,研究比较了HTLV-1携带者和HAM/TSP患者特应性反应的流行度,同时也比较了自发性的细胞因子在HTLV-1感染者个体中的产生情况。另外,一个回顾性的群体研究评估了特应性反应和非特应性反应携带者中,神经表现的发育情况。研究发现,具有高IFN-γ产生的特应

人类T淋巴细胞病毒类型1(HTLV-1)能够诱导过度的Th1响应,然而特应性反应与加剧的Th2响应相关。最近,有研究人员进行了一个代表性的研究,研究比较了HTLV-1携带者和HAM/TSP患者特应性反应的流行度,同时也比较了自发性的细胞因子在HTLV-1感染者个体中的产生情况。另外,一个回顾性的群体研究评估了特应性反应和非特应性反应携带者中,神经表现的发育情况。

研究发现,具有高IFN-γ产生的特应性HAM/TSP患者表现出了比非特应性患者更高的IL-5水平。过敏性鼻炎加速了巴宾斯基信号和过度活跃的膀胱的发展。

最后,研究人员指出,异常的Th1和Th2影响在HTLV-1感染的患者个体中共存,并且过敏性疾病也许会加重HTLV-1感染者的临床症状。

原始出处:

Verde RCL, Carneiro Neto JA, Santos SMB et al. The relationship between atopy and neurological manifestations in HTLV-1 infection. Rev Soc Bras Med Trop. 2018.

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    2018-06-06 清风拂面

    谢谢分享学习

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    2018-06-06 清风拂面

    谢谢分享学习

    0