JCEM:维生素D及体能状态与身体组成及肌肉功能存在相关性:针对一个社区常驻老年人群的五年对比研究

2014-11-09 MedSci MedSci原创

研究背景: 在老年人群中,高水平维生素D及充分的体能活动(PA)能独立改善身体组成及肌肉功能。 研究设计: 本研究基于一项针对澳大利亚社区常驻老年人的5年前瞻性人群研究。 受试者: 从选民名册中随机抽取了50岁以上的615名社区常驻志愿者(61.4±6.9岁,女性占48%),根据基线25OHD水平(≥ 或 <50nmol/L)及PA水平(≥ 或 <计步

研究背景:

在老年人群中,高水平维生素D及充分的体能活动(PA)能独立改善身体组成及肌肉功能。

研究设计:

本研究基于一项针对澳大利亚社区常驻老年人的5年前瞻性人群研究。

受试者:

从选民名册中随机抽取了50岁以上的615名社区常驻志愿者(61.4±6.9岁,女性占48%),根据基线25OHD水平(<50nmol/L)及PA水平(<计步器计量10000/天)分成高25OHDPAVitD+PA+)组、高25OHDPAVitD+PA-)组、低25OHDPAVitD-PA+)组和低25OHDPAVitD-PA-)组四组。另外,在随访过程中共有518名受试者接受了加速器评估。

主要观察指标:

记录DXA评估的身体组成和下肢肌肉功能的前后变化。

研究结果:

5年随访过程中,VitD+PA+组较其他组在体脂增加幅度显著下降(均有P < 0.05)。高水平25OHD组在5年的时间呈现出基线水平经计步器测定PA越高的受试者,总体体脂减少越多(回归分析提示β = -0.23kg100/, P = 0.001),但在25OHD低水平者中不能观察到类似的现象(P > 0.05)。在有加速器数据的受试者中,前述相关性大体上与高水平中量/大量的体能活动相关。

研究结论:

增加体能活动能减少增龄相关的体脂囤积,并且在高水平维生素D水平下这种作用得到增强,可能的机制是增加了室外中量/大量的体能活动,而不是25OHD的直接作用。

原始出处:

David Scott, Peter R. Ebeling, Kerrie M. Sanders, Dawn Aitken, Tania Winzenberg, and Graeme Jones. Vitamin D and physical activity status: Associations with five-year changes in body composition and muscle function in community-dwelling older adults. JCEM, Nov 07, 2014.

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    2015-09-17 smallant2015
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    2014-12-24 liubm568
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    2015-06-08 ljjj1053

    好好学习学习

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1777492, encodeId=aeb81e774929d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Sep 17 22:35:00 CST 2015, time=2015-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770489, encodeId=46371e70489cd, content=<a href='/topic/show?id=05fe2665508' target=_blank style='color:#2F92EE;'>#体能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26655, encryptionId=05fe2665508, topicName=体能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80ae38174281, createdName=liubm568, createdTime=Wed Dec 24 09:35:00 CST 2014, time=2014-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26336, encodeId=3d6226336fa, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 14:10:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1924113, encodeId=f8741924113e6, content=<a href='/topic/show?id=6ab89321e1b' target=_blank style='color:#2F92EE;'>#身体组成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93217, encryptionId=6ab89321e1b, topicName=身体组成)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sun Apr 19 05:35:00 CST 2015, time=2015-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837156, encodeId=4485183e1567c, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sat Sep 05 20:35:00 CST 2015, time=2015-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062873, encodeId=b06520628e303, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Apr 18 16:35:00 CST 2015, time=2015-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395608, encodeId=de3a1395608e8, content=<a href='/topic/show?id=7a89e4036eb' target=_blank style='color:#2F92EE;'>#社区#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74036, encryptionId=7a89e4036eb, topicName=社区)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Tue Nov 11 13:35:00 CST 2014, time=2014-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526725, encodeId=17301526e251f, content=<a href='/topic/show?id=f37e8012213' target=_blank style='color:#2F92EE;'>#老年人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80122, encryptionId=f37e8012213, topicName=老年人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Tue Nov 11 13:35:00 CST 2014, time=2014-11-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1777492, encodeId=aeb81e774929d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Sep 17 22:35:00 CST 2015, time=2015-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1770489, encodeId=46371e70489cd, content=<a href='/topic/show?id=05fe2665508' target=_blank style='color:#2F92EE;'>#体能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26655, encryptionId=05fe2665508, topicName=体能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80ae38174281, createdName=liubm568, createdTime=Wed Dec 24 09:35:00 CST 2014, time=2014-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26336, encodeId=3d6226336fa, content=好好学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Mon Jun 08 14:10:00 CST 2015, time=2015-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1924113, encodeId=f8741924113e6, content=<a href='/topic/show?id=6ab89321e1b' target=_blank style='color:#2F92EE;'>#身体组成#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93217, encryptionId=6ab89321e1b, topicName=身体组成)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sun Apr 19 05:35:00 CST 2015, time=2015-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837156, encodeId=4485183e1567c, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sat Sep 05 20:35:00 CST 2015, time=2015-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062873, encodeId=b06520628e303, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Sat Apr 18 16:35:00 CST 2015, time=2015-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395608, encodeId=de3a1395608e8, content=<a href='/topic/show?id=7a89e4036eb' target=_blank style='color:#2F92EE;'>#社区#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74036, encryptionId=7a89e4036eb, topicName=社区)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Tue Nov 11 13:35:00 CST 2014, time=2014-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1526725, encodeId=17301526e251f, content=<a href='/topic/show?id=f37e8012213' target=_blank style='color:#2F92EE;'>#老年人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80122, encryptionId=f37e8012213, topicName=老年人群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Tue Nov 11 13:35:00 CST 2014, time=2014-11-11, status=1, ipAttribution=)]
    2015-04-18 achengzhao
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近日,刊登在国际杂志Journal of Clinical Endocrinology & Metabolism上的一篇研究论文中,来自伊斯法罕大学的研究人员通过研究表明,维生素D缺失的个体患精神分裂症的风险是正常个体(维生素D水平充足)的两倍。维生素D可以帮助机体吸收钙质,其同样对于骨骼和肌肉的健康也至关重要,正常情况下皮肤暴露于太阳光后会产生维生素;人们通过食物比如牛奶等获得的维生素量

Acta Paediatrica:要想婴儿抵抗呼吸道感染 维生素D必不可少

据来自奥克兰大学的一项研究证实,婴儿的母亲在怀孕期服用维生素D补充剂的话,婴儿不太可能患呼吸道感染。该研究显示,相较于安慰剂组,孕期孕妇补充维生素D后,婴儿发生呼吸道感染的比例较小。这项研究结果最近发表在杂志Acta Paediatrica上。本次临床试验的主要目的,以确定维生素D的剂量对于怀孕期间孕妇是必要的,以防止婴儿维生素D不足。Grant博士说,仔细而彻底的审查基层医疗记录后,研究人员能够

Prostate:炎症或是维生素D和前列腺癌发病之间缺失的关键环节

近日,来自科罗拉多大学癌症中心的研究人员通过研究发现,炎症或许是连接维生素D和前列腺癌发病之间的一个关键点,相关研究发表于国际杂志The Prostate上。文章中,研究者指出,被维生素D上调的基因GDF-15或许在由炎症驱动的人类前列腺癌组织样本中是明显缺失的。 James R. Lambert博士表示,当服用维生素D并且作用于前列腺癌细胞时,维生素D就会抑制癌细胞的生长,但这并不能证明其

JCEM:维生素D是体外授精的关键

目前,一项大型前瞻性横断面研究结果显示,血清维生素D水平可影响体外授精成功几率。8月14日在线发表于the Journal of Clinical Endocrinology and Metabolism杂志的一项研究报告表明,行体外授精的患者其血清维生素D水平高于20 ng/mL者,获得3个或以上高质量胚胎、胚胎成功着床以及临床受孕的几率增高。 来自意大利米兰的Paffoni教授等人发

Am J Clin Nutr:维生素D或并不会阻断心脏病和中风的发生

近日,来自东安格利亚大学的研究人员通过研究表明,服用维生素D片并不能避免心脏病和中风的发生,相关研究刊登于国际杂志Am J Clin Nutr上。 近来有研究揭示维生素D水平和患多发性硬化症、糖尿病、精神分离症等病症发病数量增加直接相关;此前研究中研究人员发现,维生素D水平较低的个体更有可能患心血管疾病,而本文研究则发现维生素D的补充并不会降低个体患心血管疾病的风险,然而其却可以保护老年个体抵御

Lancet Diab & Endo:血循环25[OH]D浓度与患2型糖尿病风险的关系:孟德尔随机化研究

25[OH]D是维生素D的一种状态标志,研究已发现血循环中低的25[OH]D浓度与增加的2型糖尿病患病风险密切相关,但这种关系是否有因果关联目前还不是很清楚。为了研究25[OH]D浓度与2型糖尿病患病风险的因果关系,来自英国剑桥大学代谢科学研究所的科学家们根据多个欧洲裔人群数据源,包含患2型糖尿病与未患数据,利用单核苷酸多态性进行了一项大数据孟德尔随机化分析(研究共纳入28144病例数/76344