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PeerJ：从TCGA挖掘信息，寻找肺鳞状细胞癌诊断的生物标志物

2017-12-05 MedSci MedSci原创

肺鳞状细胞癌TCGAmiRNA
关注

肺癌被认为是全世界死亡率最高、最致命的癌症之一。寻找新的生物标志物对于早期诊断肺癌，尤其是肺鳞状细胞癌（LUSC）至关重要。癌症基因组图谱（TCGA）是提供癌症和临床信息的数据库。本研究旨在基于TCGA进行LUSC诊断性生物标志物的综合分析。研究人员从TCGA大规模样本中探究了LUSC特异性关键微小RNAs（miRNAs）。共获得332例LUSC患者临床资料相关的miRNAs表达谱。鉴定大多数在肿

肺癌被认为是全世界死亡率最高、最致命的癌症之一。寻找新的生物标志物对于早期诊断肺癌，尤其是肺鳞状细胞癌（LUSC）至关重要。癌症基因组图谱（TCGA）是提供癌症和临床信息的数据库。本研究旨在基于TCGA进行LUSC诊断性生物标志物的综合分析。

研究人员从TCGA大规模样本中探究了LUSC特异性关键微小RNAs（miRNAs）。共获得332例LUSC患者临床资料相关的miRNAs表达谱。鉴定大多数在肿瘤和正常样品之间异常表达的miRNA。采用整合计算方法，获得了42个LUSC特异性交叉点miRNAs（倍数变化> 2，p <0.05），对其中6个miRNAs在患者特征（性别、淋巴结转移及患者结局评估）进行Student t检验。通过单变量Cox比例风险回归模型和Mantel-Haenszel检验得到5个与总体生存相关的miRNAs（log-rank p <0.05）。然后，使用定量实时聚合酶链式反应随机选择5个miRNAs在47个LUSC患者组织中验证其表达。

结果显示，验证结果与TCGA的结果一致。此外，特定关键miRNA的诊断价值由受试者工作特征曲线下的面积确定。最后，选择了577个相互作用mRNA作为42个LUSC特异性相交miRNA的靶标用于进一步的生物信息学分析。

综上所述，本研究表明，基于生物信息学分析，新的microRNA表达谱可能是LUSC患者诊断的有用生物标志物。

原始出处：

Sheng Yang, Jing Sui, and Geyu Liang. Diagnosis value of aberrantly expressed microRNA profiles in lung squamous cell carcinoma: a study based on the Cancer Genome Atlas. PeerJ. 2017; 5: e4101. doi:  10.7717/peerj.4101

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    2018-03-20 sjzlzc007

    #peer#

    0

  2. 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    2018-05-28 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-10-27 feather89

    #PE#

    0

  4. 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channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jun 12 12:42:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269139, encodeId=ad7926913905, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Dec 13 14:51:05 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268502, encodeId=6a7326850234, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Dec 11 06:53:03 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267745, encodeId=e2f726e745bc, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Dec 08 07:45:44 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267680, encodeId=12af26e68059, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Dec 08 05:44:43 CST 2017, time=2017-12-08, status=1, ipAttribution=)]
    2018-02-15 zsyan

    #肺鳞状细胞癌#

    0

  5. 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level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Dec 11 06:53:03 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267745, encodeId=e2f726e745bc, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Dec 08 07:45:44 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267680, encodeId=12af26e68059, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Dec 08 05:44:43 CST 2017, time=2017-12-08, status=1, ipAttribution=)]
    2018-10-06 hukaixun

    #标志物#

    0

  6. 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channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Tue Jun 12 12:42:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269139, encodeId=ad7926913905, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Wed Dec 13 14:51:05 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268502, encodeId=6a7326850234, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Dec 11 06:53:03 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267745, encodeId=e2f726e745bc, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Dec 08 07:45:44 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267680, encodeId=12af26e68059, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Dec 08 05:44:43 CST 2017, time=2017-12-08, status=1, ipAttribution=)]
    2018-06-12 qingting

    #细胞癌#

    0

  7. 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level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Dec 11 06:53:03 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267745, encodeId=e2f726e745bc, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Dec 08 07:45:44 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267680, encodeId=12af26e68059, content=学习了谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Dec 08 05:44:43 CST 2017, time=2017-12-08, status=1, ipAttribution=)]
    2017-12-13 大爰

    学习了谢谢分享!!

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Dec 08 05:44:43 CST 2017, time=2017-12-08, status=1, ipAttribution=)]
    2017-12-11 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Dec 08 05:44:43 CST 2017, time=2017-12-08, status=1, ipAttribution=)]
    2017-12-08 大爰

    学习了谢谢分享!!

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Dec 08 05:44:43 CST 2017, time=2017-12-08, status=1, ipAttribution=)]
    2017-12-08 1e145228m78(暂无匿称)

    学习了谢谢作者分享!

    0

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