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CLIN CANCER RES：人肿瘤及正常组织ROR1蛋白表达分析

2017-07-03 MedSci MedSci原创

ROR1肿瘤表达分析
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一般认为ROR1为肿瘤特异性表达的蛋白，这使得ROR1成为肿瘤治疗的理想靶点。有许多研究团队正在开发针对ROR1的抗体或CART治疗。之前的一些研究认为ROR1在大部分正在组织中不表达。CLIN CANCER RES近期发表了一篇文章，研究人肿瘤细胞及正常组织表面ROR1表达。

一般认为ROR1为肿瘤特异性表达的蛋白，这使得ROR1成为肿瘤治疗的理想靶点。有许多研究团队正在开发针对ROR1的抗体或CART治疗。之前的一些研究认为ROR1在大部分正常组织中不表达。CLIN CANCER RES近期发表了一篇文章，研究人肿瘤细胞及正常组织表面ROR1表达。

该研究认为，对于已公开的抗体，利用免疫组化方法检测细胞表面ROR1缺乏敏感性。作者合成了一种ROR1特异性单克隆抗体并评估其在免疫组化中的敏感性及特异性。研究结果表明6D4单抗在免疫组化中检测细胞表明ROR1具有敏感性及特异性。ROR1在卵巢癌、三阴性乳腺癌以及肺腺癌中均表达。与之前研究得到的结果不同的是，该研究发现ROR1在几种正常组织中也有表达，包括甲状旁腺、胰岛以及食管、胃和十二指肠局部。6D4单抗识别恒河猴ROR1，在人类及恒河猴组织中ROR1表达相似，表明恒河猴可以作为评估ROR1靶向治疗安全性的动物模型。

文章最后认为，ROR1在许多上皮肿瘤中是具有前景的免疫治疗靶点。但是在多种正常组织表明高表达的ROR1使得治疗毒性反应成为问题。临床中应用靶向ROR1治疗需密切监控健康器官的毒性反应，保障患者安全。

原始出处：
Ashwini Balakrishnan,Tracy Goodpaster,et al.Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues.CLIN CANCER RES.June 2017 doi:10.1158/1078-0432.CCR-16-2083

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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219429, encodeId=4d042194294c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Fri Jul 07 08:38:09 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219121, encodeId=6dc32191218e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Thu Jul 06 09:53:31 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218840, encodeId=6c8221884013, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 05 14:41:47 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532651, encodeId=da37153265193, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Wed Jul 05 09:47:00 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-10 1e1b8c04m38(暂无匿称)

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1936621, encodeId=abf4193662178, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Thu May 17 07:47:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221375, encodeId=84892213e51e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 12 09:25:09 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220969, encodeId=e67e220969a4, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Tue Jul 11 08:53:21 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220740, encodeId=5d78220e40e5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Mon Jul 10 14:36:09 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219429, encodeId=4d042194294c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Fri Jul 07 08:38:09 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219121, encodeId=6dc32191218e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Thu Jul 06 09:53:31 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218840, encodeId=6c8221884013, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 05 14:41:47 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532651, encodeId=da37153265193, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Wed Jul 05 09:47:00 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-09 1e1b8c04m38(暂无匿称)

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1936621, encodeId=abf4193662178, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Thu May 17 07:47:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221375, encodeId=84892213e51e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 12 09:25:09 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220969, encodeId=e67e220969a4, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Tue Jul 11 08:53:21 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220740, encodeId=5d78220e40e5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Mon Jul 10 14:36:09 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219429, encodeId=4d042194294c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Fri Jul 07 08:38:09 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219121, encodeId=6dc32191218e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Thu Jul 06 09:53:31 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218840, encodeId=6c8221884013, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 05 14:41:47 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532651, encodeId=da37153265193, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Wed Jul 05 09:47:00 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-08 1e1b8c04m38(暂无匿称)

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1936621, encodeId=abf4193662178, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Thu May 17 07:47:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221375, encodeId=84892213e51e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 12 09:25:09 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220969, encodeId=e67e220969a4, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Tue Jul 11 08:53:21 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220740, encodeId=5d78220e40e5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Mon Jul 10 14:36:09 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219429, encodeId=4d042194294c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Fri Jul 07 08:38:09 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219121, encodeId=6dc32191218e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Thu Jul 06 09:53:31 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218840, encodeId=6c8221884013, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 05 14:41:47 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532651, encodeId=da37153265193, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Wed Jul 05 09:47:00 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-07 1e1b8c04m38(暂无匿称)

    学习

    0

  8. 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time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218840, encodeId=6c8221884013, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 05 14:41:47 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532651, encodeId=da37153265193, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Wed Jul 05 09:47:00 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-06 1e1b8c04m38(暂无匿称)

    学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1936621, encodeId=abf4193662178, content=<a href='/topic/show?id=20f5902e082' target=_blank style='color:#2F92EE;'>#表达分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90270, encryptionId=20f5902e082, topicName=表达分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Thu May 17 07:47:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221375, encodeId=84892213e51e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 12 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219429, encodeId=4d042194294c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Fri Jul 07 08:38:09 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219121, encodeId=6dc32191218e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Thu Jul 06 09:53:31 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218840, encodeId=6c8221884013, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 05 14:41:47 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532651, encodeId=da37153265193, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Wed Jul 05 09:47:00 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-05 1e1b8c04m38(暂无匿称)

    学习

    0

  10. 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09:25:09 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220969, encodeId=e67e220969a4, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Tue Jul 11 08:53:21 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220740, encodeId=5d78220e40e5, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Mon Jul 10 14:36:09 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time=2017-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219429, encodeId=4d042194294c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Fri Jul 07 08:38:09 CST 2017, time=2017-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=219121, encodeId=6dc32191218e, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Thu Jul 06 09:53:31 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218840, encodeId=6c8221884013, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161217/IMG585499DFC35A96490.jpg, createdBy=72381996390, createdName=1e1b8c04m38(暂无匿称), createdTime=Wed Jul 05 14:41:47 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532651, encodeId=da37153265193, content=<a href='/topic/show?id=f33388695c2' target=_blank style='color:#2F92EE;'>#蛋白表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88695, encryptionId=f33388695c2, topicName=蛋白表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79512374813, createdName=xuyu, createdTime=Wed Jul 05 09:47:00 CST 2017, time=2017-07-05, status=1, ipAttribution=)]
    2017-07-05 xuyu

    #蛋白表达#

    0

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