Gastroenterology & CGH:多研究聚焦肝脏疾病新疗法

2014-11-25 佚名 生物谷

肝硬化及非酒精性脂肪肝(NAFLD)是两种严重的肝脏疾病,目前治疗这两种肝脏疾病的疗法非常有限,而近日刊登在国际杂志Clinical Gastroenterology and Hepatology和Gastroenterology的三篇研究论文中,研究人员揭示了当前治疗肝硬化及非酒精性脂肪肝的最新疗法进展。 首先刊登在Gastroenterology上的研究论文中,研究者发现,超过6个月每天

肝硬化及非酒精性脂肪肝(NAFLD)是两种严重的肝脏疾病,目前治疗这两种肝脏疾病的疗法非常有限,而近日刊登在国际杂志Clinical Gastroenterology and HepatologyGastroenterology的三篇研究论文中,研究人员揭示了当前治疗肝硬化及非酒精性脂肪肝的最新疗法进展。

首先刊登在Gastroenterology上的研究论文中,研究者发现,超过6个月每天摄入名为VSL#3®的益生菌可明显改善肝硬化患者的肝功能,并且降低患者入院的风险;接受该益生菌治疗的病人同样也会降低肝性脑病的发生率,目前该益生菌治疗并没有相关的不良事件报告。

发表在Clinical Gastroenterology and Hepatology杂志上的第二篇研究论文中,研究者表示,连续三个月的脂肪酸-胆酸耦合物Aramchol的服用是安全的,而且可以明显非酒精性脂肪肝患者肝脏中的脂肪含量,肝脏脂肪含量的降低往往具有剂量依赖性,而且和患者的代谢改善直接相关,这就意味着,Aramchol或许是一种治疗脂肪肝相关疾病的新型疗法的候选药物。

研究者通过研究发现,相比对照组而言,进行8周白藜芦醇的摄入并不会对非酒精性脂肪肝男性带来治疗的效益;同时研究人员也提醒患慢性肝病的肥胖个体慎用。相关研究由丹麦亚历山德拉公主研究基金会等机构提供资助。

原始出处

Radha K. Dhiman, Baldev Rana, Swastik Agrawal, Ashish Garg, Madhu Chopra, Kiran K. Thumburu, Amit Khattri, Samir Malhotra, Ajay Duseja, Yogesh K. Chawla .Probiotic VSL#3 Reduces Liver Disease Severity and Hospitalization in Patients With Cirrhosis: A Randomized, Controlled Trial .Gastroenterology & CGH.2014

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    2015-08-12 chendoc242
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    2015-08-24 许安
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    2014-11-27 kcb074

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