JAMA Neurol:皮质下微梗死人群的血压轨迹异常

2017-12-06 zhangfan MedSci原创

研究认为,皮质下微梗死与血压下降相关,这一发现为风险人群的临床监控提供了依据

脑微梗死与认知障碍相关,且与较大梗死相比对多种疾病风险存在差异。近日研究人员考察了皮质下微梗死与血压下降之间的关系。

以人口为基础的梅奥衰老研究中,研究人员对303人进行了尸检,将微梗死区分为皮质或皮质下微梗死,比较无微梗死、皮质下梗死、皮质梗死患者基线和血压轨迹差异,采用二次逻辑回归分析评估皮质下微梗死与中年高血压、收缩压和舒张压波动之间的关系。

303名尸检者中,297人血压数据可获得,其中男性占59.6%,死亡年龄87.2岁。297人中,47人(15.8%)为慢性微梗死,其中男性占63.8%。30人(63.8%)为皮质微梗死、19人(40.4%)为皮质下微梗死、4人(8.5%)为小脑微梗死。微梗死患者基线收缩以及舒张压与无微梗死人群无显著差异,但皮质下微梗死人群年均收缩(斜率差异,4.66;95% CI, 0.13-9.19; P=0.04)以及舒张压(斜率差异,3.33; 95% CI,0.61- 6.06; P=0.02)下降更为显著。

研究认为,皮质下微梗死与血压下降相关,这一发现为风险人群的临床监控提供了依据。

原始出处:

Jonathan Graff-Radford et al. Association Between Microinfarcts and Blood Pressure Trajectories. JAMA Neurol. December 4 2017.

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    2018-10-26 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=2000210, encodeId=d6fc200021009, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Oct 26 01:17:00 CST 2018, time=2018-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268368, encodeId=1ab72683680e, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Dec 10 13:01:17 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267280, encodeId=a4c426e280a4, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Dec 06 14:13:45 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267272, encodeId=1e0c26e272a4, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 06 14:03:39 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267249, encodeId=19e326e2491f, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Dec 06 12:27:39 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267242, encodeId=dc0126e242ca, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Wed Dec 06 12:04:18 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-10 131****1460

    学习了受益匪浅

    0

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    2017-12-06 131****1460

    学习了受益匪浅

    0

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    2017-12-06 Y—xianghai

    学习了新知识

    0

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    2017-12-06 flysky120

    学习一下知识了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2000210, encodeId=d6fc200021009, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Oct 26 01:17:00 CST 2018, time=2018-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268368, encodeId=1ab72683680e, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Dec 10 13:01:17 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267280, encodeId=a4c426e280a4, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Dec 06 14:13:45 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267272, encodeId=1e0c26e272a4, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Dec 06 14:03:39 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267249, encodeId=19e326e2491f, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Wed Dec 06 12:27:39 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267242, encodeId=dc0126e242ca, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Wed Dec 06 12:04:18 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-06 swfzhanggui

    非常好.谢谢分享

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