Diabetes Res Clin Pr：TID儿童应该减少果糖的摄入

以往的研究显示，在成人，膳食果糖的高消耗引起血脂异常和血压升高，但在青少年，这方面的数据很少，特别是对那些处于心血管疾病（CVD）高风险的青少年。在1型糖尿病（T1D）青少年的多样化人群中，为了验证果糖摄入与CVD危险因素的关系。来自美国辛辛那提大学医学中心的Sarah C Couch教授及其团队进行了一项研究，该研究发现TID儿童，特别是那些伴有临界甘油三脂或高甘油三脂的儿童，应该减少果糖的摄入。该研究结果在线发表在3月26日的《糖尿病研究与临床实践》杂志上。

该研究是一项横断面研究，数据来自青年糖尿病探索研究，包括2085例年龄10–22岁的青年T1D患者，22%为少数种族/族裔，而且，50%为女性。使用半定量食物频率问卷评估摄入量。

该研究结果表明，膳食果糖消耗中位数为总卡路里的7.9%。在校正体力活动以及社会人口、临床和饮食协变量后，果糖摄入与甘油三脂呈正相关（p＜0.01），但与总胆固醇、LDL–胆固醇、HDL–胆固醇、或血压不相关。果糖摄入增加22g（与12盎司苏打等价）与临界/高甘油三酯对低甘油三酯几率增加23%相关（p＜0.005）。

该研究发现，TID儿童，特别是那些伴有临界甘油三脂或高甘油三脂的儿童，应该减少果糖的摄入。

Fructose intake and cardiovascular risk factors in youth with type 1 diabetes: SEARCH for diabetes in youth study.
AIMS
High consumption of dietary fructose has been shown to contribute to dyslipidemia and elevated blood pressure in adults, but there are few data in youth, particularly those at greater risk of cardiovascular disease (CVD). The aim of this study was to examine the association between fructose intake and CVD risk factors in a diverse population of youth with type 1 diabetes (T1D).
METHODS
This was a cross-sectional analysis of data from the SEARCH for Diabetes in Youth study, including 2085 youth ages 10-22 years with T1D, of which 22% were racial/ethnic minority and 50% were female. A semi-quantitative food frequency questionnaire was used to assess intake.
RESULTS
Median daily fructose consumption was 7.9% of total calories. Fructose intake was positively associated with triglycerides (p<.01), but not with total cholesterol, LDL-cholesterol, HDL-cholesterol, or blood pressure after adjustment for physical activity and socio-demographic, clinical, and dietary covariates. An increase in fructose intake of 22g (equivalent to a 12oz can of soda) was associated with 23% higher odds of borderline/high versus low triglycerides (p<.005).
CONCLUSION
These data suggest that children with T1D should moderate their intake of fructose, particularly those with borderline or high triglycerides.