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PLOS ONE：非小细胞肺腺癌生存期的不利独立预后指标

2018-05-12 海北 MedSci原创

非小细胞肺腺癌生存期
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来自宜宾市第一人民医院的研究人员通过使用癌症基因组图谱（TCGA）- 肺腺癌（LUAD）中的数据进行了回顾性研究，探讨了S100A16在总生存期（OS）和无复发生存期（RFS）方面的独立预后价值。

S100A16是哺乳动物中S100蛋白家族的保守成员。其在许多肿瘤中被观察到有所上调，且与恶性转化有关。

在这项研究中，来自宜宾市第一人民医院的研究人员通过使用癌症基因组图谱（TCGA）- 肺腺癌（LUAD）中的数据进行了回顾性研究，探讨了S100A16在总生存期（OS）和无复发生存期（RFS）方面的独立预后价值。此外，通过在TCGA-LUAD中使用深度测序数据，研究人员还探索了S100A16表达与其DNA甲基化和拷贝数改变（CNA）之间的关联。

结果显示，与正常肺组织（N = 59）相比，初级LUAD组织（N = 514）具有显着升高的S100A16表达。根据502例原发性LUAD病例的OS数据，研究人员发现高S100A16表达与较差的OS相关。单变量和多变量分析也证实，S100A16的表达增加是不利OS（HR：1.197,95％CI：1.050-1.364，p = 0.007）和RFS（HR：1.206,95％CI：1.045-1.393 ，p = 0.011）的独立预后指标。

通过检测TCGA-LUAD中的DNA甲基化数据，研究人员发现一些S100A16 DNA CpG位点通常在正常组织中超甲基化，但在LUAD组织中不存在。回归分析发现S100A16表达与其DNA甲基化之间呈中度负相关。

相比之下，尽管在LUAD患者中DNA扩增（+ 1 / + 2）频繁（378/511，74％），但与S100A16表达增加无关。

基于上述发现，研究人员推断，异常的S100A16表达可能受其DNA低甲基化调节，并能够作为LUAD中不利OS和RFS的独立预后指标。


原始出处：

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    2019-04-25 119337457

    #Plos one#

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    2018-10-31 lingaifan

    #非小细胞#

    0

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    2018-05-22 zdvfsadb

    学习了

    0

  4. 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createdName=jihuaijun1112, createdTime=Wed May 16 15:00:44 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315166, encodeId=f2b531516690, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue May 15 00:55:21 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-20 jihuaijun1112

    学习学习学习

    0

  5. 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    2018-05-20 jihuaijun1112

    学习学习学习

    0

  6. 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createdName=jihuaijun1112, createdTime=Wed May 16 15:00:44 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315166, encodeId=f2b531516690, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue May 15 00:55:21 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-19 jihuaijun1112

    学习学习学习

    0

  7. 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    2018-05-18 jihuaijun1112

    学习学习学习

    0

  8. 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    2018-05-17 jihuaijun1112

    学习学习学习

    0

  9. 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    2018-05-16 jihuaijun1112

    学习学习学习学习学习学习

    0

  10. 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createdName=jihuaijun1112, createdTime=Wed May 16 15:00:44 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315166, encodeId=f2b531516690, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue May 15 00:55:21 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-15 jihuaijun1112

    学习学习学习

    0

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