J Urol:青春期精索静脉曲张男性的总能动精子数与激素水平和睾丸总体积有关

2020-10-29 AlexYang MedSci原创

患有精索静脉曲张青少年中,关于未来不育的风险因素存在争议,且对激素水平和精液参数之间的关系知之甚少。精液分析(SA)可能是最接近生育能力的标志物,但在一些男孩中可能难以获得,主要是因为一些个人、家庭或

患有精索静脉曲张青少年中,关于未来不育的风险因素存在争议,且对激素水平和精液参数之间的关系知之甚少。精液分析(SA)可能是最接近生育能力的标志物,但在一些男孩中可能难以获得,主要是因为一些个人、家庭或宗教原因。确定异常精液参数的其他临床替代物能够为评估这些男孩的精索静脉曲张严重程度提供选择。最近,有研究人员假设了激素水平和TTV可以预测TMSC的异常。

研究包括了78名男孩(中位年龄17.5岁)。研究发现,LH、AMH和总睾酮与任何SA参数均无相关性。FSH与TMSC之间呈现负相关关系(ρ=-0.35,p=0.004),抑制素B与TMSC之间呈现正相关关系(ρ=0.50,p<0.001)。另外,TTV与TMSC显著正相关(ρ=0.35,p=0.01)。ROC分析显示,预测异常TMSC的最佳FSH截断值为2.9,最佳inhibinB截断值为204,最佳TTV截止值为34.4cc。

与异常TMSC相关的3种风险因素最终优化截断值

最后,研究人员指出,TMSC与FSH水平成反比,与抑制素B水平和TTV直接相关。血清FSH、抑制素B和TTV的优化截断值可以成为因个人或宗教/文化原因推迟SA男孩TMSC的合理代用指标。

原始出处:

Jason P Van Batavia , Elizabeth Lawton , Jennifer R Frazier et al. Total Motile Sperm Count in Adolescent Boys with Varicocele is Associated with Hormone Levels and Total Testicular Volume. J Urol. Oct 2020

 

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    2021-04-06 fusion
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    2020-10-31 zhangph

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