IBD: 难治性溃疡性结肠炎手术患者的肠系膜静脉血栓形成的危险因素

2020-01-18 不详 MedSci原创

肠系膜静脉血栓形成(PMVT)是结直肠手术公认的危险术后并发症。本项研究的目的是探究因难治性溃疡性结肠炎(UC)接受手术的患者中PMVT的发生率和危险因素。

背景
肠系膜静脉血栓形成(PMVT)是结直肠手术公认的危险术后并发症。本项研究的目的是探究因难治性溃疡性结肠炎(UC)接受手术的患者中PMVT的发生率和危险因素。

方法
研究人员回顾性分析了2010年1月至2016年12月期间在三级护理中心接受手术的难治性UC患者的临床资料。PMVT被定义为术后腹部CT扫描中门静脉,脾静脉,肠系膜上静脉或肠系膜下静脉内的血栓出现。在多变量分析中探究了与单因素分析中与PMVT相关的因素。通过受试者工作特征曲线和Kaplan-Meier曲线检查危险因素的临床相关性。

结果
本项研究总共确定了434名患者。428例(98.5%)住院患者接受了术后静脉血栓栓塞(VTE)预防,平均持续时间为7.7±0.17天。在36例(8.3%)的患者中出现PNVT,PMVT平均发生时间为术后55.3±10.8天。大部分PMVT发生在结肠大部切除术之后,最常见的最初症状是腹痛。术前C反应蛋白(CRP)与PMVT相关(比值比为1.01;95%可信区间为1.00–1.02;P=0.01),最佳预测CRP阈值为45 mg/L。CRP> 45 mg / L的患者PMVT发生率更高(P = 0.01)。

结论
PMVT可表现为腹痛,并在出院后数周发生。

原始出处:

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    2020-08-03 xue8602
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    2020-09-15 fusion
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    2020-02-02 nymo
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    2020-01-20 bnurmamat
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    2020-01-20 freve
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    2020-01-20 zzc2216

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