JACC:老年心肌梗死(MI)并且有院外心脏骤停的患者出院后生存率较好

2016-04-26 MedSci MedSci原创

院外心脏骤停(OHCA)与急性心肌梗死(MI)有关,并导致较高的住院死亡率;然而,在那些幸存的患者中,很少有人知道关于他们出院后的死亡率和健康护理使用率。这项研究的目的是确定老年MI幸存者(有和没有OHCA)的出院后1年生存率和再住院率。研究人员链接到急性冠脉治疗和干预成果网络注册表的指南和医疗数据,这项研究分析了54860例MI患者,年龄超过65岁,在2011年4月和2012年12月之间从545

院外心脏骤停(OHCA)与急性心肌梗死(MI)有关,并导致较高的住院死亡率;然而,在那些幸存的患者中,很少有人知道关于他们出院后的死亡率和健康护理使用率。

这项研究的目的是确定老年MI幸存者(有和没有OHCA)的出院后1年生存率和再住院率。

研究人员链接到急性冠脉治疗和干预成果网络注册表的指南和医疗数据,这项研究分析了54860例MI患者,年龄超过65岁,在2011年4月和2012年12月之间从545家美国医院幸存出院。多变量模型检验了MI-相关的OHCA与出院后1年的死亡率或全因再住院率之间的关联。出院后进行临终关怀的患者被排除在外,因为他们已知的预后较差。

出院后,与无OHCA的老年MI幸存者相比(n=54219),那些OHCA患者(n=641,1.2%)更可能是年轻男性,和吸烟者,但不太可能有糖尿病,心脏衰竭,或之前有血运重建。OHCA患者ST段抬高心肌梗死(63.2% vs 29.6%)和心源性休克(29.0% vs 2.2%)出现更频繁;然而,在院内MI幸存者中,OHCA不与1年后的死亡率相关(未经调整的13.8% vs 15.8%,P=0.17,调整后的危险比[HR]:0.89;95%可信区间[CI] :0.68〜1.15)。相比之下,有OHCA的MI幸存者比无OHCA患者有较低的1年死亡率或全因再入院率复合终点的未调整和调整后的风险(44.0% vs 50.0%,P=0.03,调整的HR:0.84;95 %CI:0.72〜0.97)。

在老年MI幸存至出院,并且没有安排到临终关怀的患者中,那些有OHCA的患者与无OHCA的MI幸存者相比,1年死亡率或卫生保健利用率并不高。这些结果表明,OHCA患者不良事件的早期风险在出院后并没有继续存在,这些研究支持改善老年MI和OHCA患者的最初的生存率。

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    2017-04-12 hbwxf
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    2016-05-01 lshanp

    多少有点意外,临床实践出真知

    0

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背景:冠状动脉支架术后,糖尿病(DM)患者复发性脑缺血事件发生的风险很高。研究者评估参与双联抗血小板治疗研究(DAPT)中糖尿病患者持续应用噻吩并吡啶的影响。方法:冠状动脉内支架植入术后,噻吩吡啶类药物加阿司匹林治疗12个月。11648例非缺血性或出血事件的患者,根据用药随机分为持续的噻吩吡啶类药物联合阿司匹林或安慰剂联合阿司匹林。结果:与非糖尿病患者(8257例)相比,糖尿病患者(3391例)死