ARD:利用CT检查可定量测量强直性脊柱炎韧带骨赘体积和高度

2014-03-12 佚名 丁香园

众所周知,普通X线摄像技术局限于清晰度以及定量评分方法,很难对强直性脊柱炎(AS)的韧带骨赘生长进行评估。来自美国NIH的Sovira Tan等人利用CT扫描技术对AS韧带骨赘体积和高度进行定量评估,并探讨此方法的可靠性和效度。 该研究对38名AS患者进行腰椎CT扫描,并对其韧带骨赘体积和高度进行定量计算。为了评估此方法的可靠性,他们比较了来自2个机器同一天对9位AS患者扫描的结果。为了评估有效

众所周知,普通X线摄像技术局限于清晰度以及定量评分方法,很难对强直性脊柱炎(AS)的韧带骨赘生长进行评估。来自美国NIH的Sovira Tan等人利用CT扫描技术对AS韧带骨赘体积和高度进行定量评估,并探讨此方法的可靠性和效度。

该研究对38名AS患者进行腰椎CT扫描,并对其韧带骨赘体积和高度进行定量计算。为了评估此方法的可靠性,他们比较了来自2个机器同一天对9位AS患者扫描的结果。为了评估有效性,他们比较了此种计算方法与两位医师对韧带骨赘体积和高度CT扫描及X线扫描的视觉评级结果。

应用该方法重复测量韧带骨赘体积和高度,变异系数分别为2.05%和2.40%。基于Bland-Altman分析,韧带骨赘体积增加超过4%/韧带骨赘高度超过0.20毫米,此变化大于测量误差。计算出的韧带骨赘体积和高度与医师对CT扫描( P <0.0001)和X线扫描( P < 0.002 )结果的目视检查评级具有强烈的相关性。韧带骨赘的体积也与Schober检测(r=-0.48)和胸腰椎侧弯相关(r=-0.60)。

这种新的基于CT扫描基础上的测量方法可以充分量化韧带骨赘的三维成像,具有良好的可靠性以及面和结构的效度。鉴于其较高的精确度,可以为临床对韧带骨赘发展和生长的纵向研究提供良好的数据保证。

原始出处

Tan S1, Yao J, Flynn JA, Yao L, Ward MM.Quantitative measurement of syndesmophyte volume and height in ankylosing spondylitis using CT.Ann Rheum Dis. 2014 Mar 1

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    2014-06-20 zywlvao
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    2014-03-14 kzlchina
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