Materials:OGI表面可促进间充质干细胞的成骨及成血管作用

2017-12-01 MedSci MedSci原创

在牙种植体骨整合过程中,成骨则是基本的作用。在本研究中,我们研究了骨生长诱导(OGI)表面特性对间充质干细胞(MSC)血管生成和成骨行为的影响。在OGI钛表面上培养来自牙髓和HUVEC(人脐静脉内皮细胞)的MSCs,使用MTT测试和DNA定量分析细胞增殖和DNA合成的情况。基因表达分析用以评估与内皮和成骨标志相关的mRNA的表达。此外,进行成骨形成的形态学和生物化学分析。结果显示,在OGI表面上,

在牙种植体骨整合过程中,成骨则是基本的作用。在本研究中,我们研究了骨生长诱导(OGI)表面特性对间充质干细胞(MSC)血管生成和成骨行为的影响。

在OGI钛表面上培养来自牙髓和HUVEC(人脐静脉内皮细胞)的MSCs,使用MTT测试和DNA定量分析细胞增殖和DNA合成的情况。基因表达分析用以评估与内皮和成骨标志相关的mRNA的表达。此外,进行成骨形成的形态学和生物化学分析。

结果显示,在OGI表面上,MSC和HUVEC能够增殖。基因表达谱分析证实,OGI表面上的MSC能够表达内皮和成骨标记,且其表达的水平高于对照组。

总之,该研究结果表明,OGI表面可促进MSC和HUVEC的增殖,并促进MSC中血管生成相关标志物的表达。

原始出处:

Ghensi P, Bressan E, et al., The Biological Properties of OGI Surfaces Positively Act on Osteogenic and Angiogenic Commitment of Mesenchymal Stem Cells. Materials (Basel). 2017 Nov 17;10(11). pii: E1321. doi: 10.3390/ma10111321.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1815275, encodeId=312918152e56d, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Mar 31 06:39:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351633, encodeId=4a0b13516334e, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Dec 03 13:39:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266043, encodeId=286d266043cb, content=在牙种植体骨整合过程中.成骨则是基本的作用.在本研究中.我们研究了骨生长诱导(OGI)表面特性对间充质干细胞(MSC)血管生成和成骨行为的影响., beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Dec 01 23:39:52 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266028, encodeId=1897266028b6, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Dec 01 22:40:59 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-03 zhaojie88
  3. [GetPortalCommentsPageByObjectIdResponse(id=1815275, encodeId=312918152e56d, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Mar 31 06:39:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351633, encodeId=4a0b13516334e, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Dec 03 13:39:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266043, encodeId=286d266043cb, content=在牙种植体骨整合过程中.成骨则是基本的作用.在本研究中.我们研究了骨生长诱导(OGI)表面特性对间充质干细胞(MSC)血管生成和成骨行为的影响., beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Dec 01 23:39:52 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266028, encodeId=1897266028b6, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Dec 01 22:40:59 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-01 有备才能无患

    在牙种植体骨整合过程中.成骨则是基本的作用.在本研究中.我们研究了骨生长诱导(OGI)表面特性对间充质干细胞(MSC)血管生成和成骨行为的影响.

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1815275, encodeId=312918152e56d, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Mar 31 06:39:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351633, encodeId=4a0b13516334e, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Dec 03 13:39:00 CST 2017, time=2017-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266043, encodeId=286d266043cb, content=在牙种植体骨整合过程中.成骨则是基本的作用.在本研究中.我们研究了骨生长诱导(OGI)表面特性对间充质干细胞(MSC)血管生成和成骨行为的影响., beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Dec 01 23:39:52 CST 2017, time=2017-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266028, encodeId=1897266028b6, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Dec 01 22:40:59 CST 2017, time=2017-12-01, status=1, ipAttribution=)]
    2017-12-01 1e1b8538m79(暂无匿称)

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