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J Clin Endocrinol Metab：不同减肥手术对能量代谢适应和心脏代谢改善研究

2016-08-05 Mechront 译 MedSci原创

减肥能量代谢适应心脏代谢
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目的：比较Roux-en-Y旁路（RYGB）、袖状胃切除术（SG）、腹腔镜可调节胃束带（LAGB）、低热量饮食（LCD）后8周和1年的能量消耗(代谢室)变化。方法：纳入30名患者进行前瞻性观察性研究（27例女性，46±2岁，BMI = 47.2±1.5kg/m2），参与者自行选择减肥手术（RYGB = 5，SG = 9，LAGB = 7）或LCD（n = 9）干预（800kcal /天，8周后维持

目的：比较Roux-en-Y旁路（RYGB）、袖状胃切除术（SG）、腹腔镜可调节胃束带（LAGB）、低热量饮食（LCD）后8周和1年的能量消耗(代谢室)变化。

方法：纳入30名患者进行前瞻性观察性研究（27例女性，46±2岁，BMI = 47.2±1.5kg/m2），参与者自行选择减肥手术（RYGB = 5，SG = 9，LAGB = 7）或LCD（n = 9）干预（800kcal /天，8周后维持体重）。

结果：1年后，RYGB和SG组体重下降程度相似(33-36%)，不过LAGB和LCD组体重分别下降16%和4%。调整身体成分的变化后，第8周所有治疗组患者的24小时能量消耗显著下降(-254~-82kcal/天)，只有RYGB组(-124±42kcal/天; p=0.002)和SG组(-155±118kcal/天; p=0.02)在第1年时持续下降。不同治疗组患者在任一时间点的代谢适应（24小时和睡眠能量消耗）的程度没有显著差异。RYGB或SG后1年血浆HDL和总脂联素和高分子量脂联素增加，甘油三酯和hsCRP水平降低。

结论：RYGB和SG手术可出现∼150kcal/天的代谢适应。未来的研究是必要的，以检查这些影响超过1年后是否仍存在。

原始出处：

Tam CS, Redman LM.et al.Energy metabolic adaptation and cardiometabolic improvements one year after gastric bypass, sleeve gastrectomy and gastric band.J Clin Endocrinol Metab. 2016 Aug 4:jc20161814. [Epub ahead of print]

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    2016-08-08 guojianrong

    #Meta#

    0

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    2016-10-19 智智灵药

    #MET#

    0

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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Aug 07 11:54:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96338, encodeId=e0b99633881, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 09:04:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-09-23 1e10c84am36(暂无匿称)

    深度好文，值得学习

    0

  4. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Aug 07 11:54:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96338, encodeId=e0b99633881, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 09:04:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-09-20 1e10c84am36(暂无匿称)

    文章很好，非常有益

    0

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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Aug 07 11:54:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96338, encodeId=e0b99633881, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 09:04:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-09-16 1e10c84am36(暂无匿称)

    不错哦，会学到很多

    0

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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Aug 07 11:54:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96338, encodeId=e0b99633881, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 09:04:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-09-12 舒心和人

    处处留心皆学问，开阔眼界拓宽研究思路，学习了，感谢分享

    0

  7. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIUEDhSibBFt8TicgFCCSBtW10SxVJicDpibTCucns8L1YaiaKpibWOkv8hYpJ0LeTVUH1Ab4sfica9bxiccA/132, createdBy=dd282500126, createdName=ms3830150583600765, createdTime=Sun Aug 07 11:54:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96338, encodeId=e0b99633881, content=学习了，赞一个！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 09:04:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好，不错，以后会多学习

    0

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    2016-08-07 amyloid

    #能量代谢#

    0

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    2016-08-07 ms3830150583600765

    #心脏代谢#

    0

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    2016-08-06 1dd8a7c5m95(暂无匿称)

    学习了，赞一个！！

    0

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