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NEJM：M72/AS01E疫苗可有效预防潜伏性肺结核感染

2018-09-26 zhangfan MedSci原创

肺结核疫苗M72/AS01E
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研究认为M72/AS01E对潜伏性结核感染的预防有效率为54%

近日研究人员公布了新型结核疫苗M72/AS01E的II期临床结果。

本次研究在非洲多国开展，HIV阴性的成年潜伏性结核病感染患者参与研究，随机接受2剂量的M72/AS01E或安慰剂。研究的主要终点为安全性以及对经细菌证实的活动性肺结核病发病。

研究平均随访2.3年，总计1786人接受疫苗，1787人接受安慰剂。疫苗组10名患者经细菌证实患活动性肺结核病，安慰剂组22人患病，每100随访年发病率分别为0.3例和0.6例。疫苗的有效率为54.0%。疫苗接种组67.4%的患者在30天内出现不良事件，主要是流感样症状，安慰剂组不良事件率为45.4%。

研究认为M72/AS01E对潜伏性结核感染的预防有效率为54%。

原始出处：

Olivier Van Der Meeren et al. Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis. N Engl J Med， September 25， 2018.

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    2019-09-01 swallow

    #结核感染#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1721515, encodeId=f6931e21515e1, content=<a href='/topic/show?id=12cae864776' target=_blank style='color:#2F92EE;'>#结核感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78647, encryptionId=12cae864776, topicName=结核感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a1433017007, createdName=swallow, createdTime=Sun Sep 01 11:09:00 CST 2019, time=2019-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634181, encodeId=a024163418175, content=<a href='/topic/show?id=020b111961d' target=_blank style='color:#2F92EE;'>#M72/AS01E#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11196, encryptionId=020b111961d, topicName=M72/AS01E)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3fa922077998, createdName=bbwuyu_010, createdTime=Sun Apr 28 03:09:00 CST 2019, time=2019-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1254218, encodeId=046b1254218d8, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Fri Sep 28 01:09:00 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346706, encodeId=9af0346e067a, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Sep 26 10:14:36 CST 2018, time=2018-09-26, status=1, ipAttribution=)]
    2019-04-28 bbwuyu_010

    #M72/AS01E#

    0

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    2018-09-28 huhuaidong387

    #结核#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1721515, encodeId=f6931e21515e1, content=<a href='/topic/show?id=12cae864776' target=_blank style='color:#2F92EE;'>#结核感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78647, encryptionId=12cae864776, topicName=结核感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5a1433017007, createdName=swallow, createdTime=Sun Sep 01 11:09:00 CST 2019, time=2019-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634181, encodeId=a024163418175, content=<a href='/topic/show?id=020b111961d' target=_blank style='color:#2F92EE;'>#M72/AS01E#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11196, encryptionId=020b111961d, topicName=M72/AS01E)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3fa922077998, createdName=bbwuyu_010, createdTime=Sun Apr 28 03:09:00 CST 2019, time=2019-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1254218, encodeId=046b1254218d8, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Fri Sep 28 01:09:00 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346706, encodeId=9af0346e067a, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Sep 26 10:14:36 CST 2018, time=2018-09-26, status=1, ipAttribution=)]
    2018-09-26 明月清辉

    谢谢分享，学习了

    0

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