Int J Epidemiol:出生体重会影响晚年的左心室结构吗?

2016-09-27 Moon 译 MedSci原创

高左心室质量(LVM)是心血管疾病和死亡率的独立预测因子。我们进行了一项研究,评估出生体重、升高和BMI,以及儿童期和青少年时间超重,与晚年(60-64岁)左心室(LV)结构之间的关系。 研究纳入了出生于英国、1946年的参与者,自出生开始进行随访。数据来自MRC全国性健康和发展调查(NSHD)。我们使用回归模型,评估出生体重、身高、BMI与60-64岁时LV结构之间的联系。 结果表明

高水平的左心室质量(LVM)是心血管疾病和死亡率的独立预测因子。我们进行了一项研究,评估出生体重、身高和BMI,以及儿童期和青少年时间超重,与晚年(60-64岁)左心室(LV)结构之间的关系。

研究纳入了1946年出生于英国的参与者,自出生开始进行随访。数据来自MRC全国性健康和发展调查(NSHD)。我们使用回归模型,评估出生体重、身高、BMI与60-64岁时LV结构之间的联系。

结果表明,出生体重与60-64岁时的LVM和左室舒张末期容积(LVEDV)呈正相关,成年身高是这种关联性的主要原因。整个童年和青少年时期,更高的BMI、更大的BMI变化和更大的累积超重,与更高的LVM、LVEDV和向心性肥厚几率有关。

生命头两年超重的参与者,与不超重的参与者相比,平均LVM高出11.5 g(95% CI -2.19,24.87),平均LVEDV高出10.0 ml(3.7,16.2)。这种联系的部分原因可能是成人的BMI。

身体大小与相对壁厚(RWT)的关联性结果不一致,青春期的BMI变化与RWT关联最密切(7-15岁,BMI每变化1SD,0.007 (0.001,0.013))。更高的儿童身高与LVM和LVEDV之间的联系,可以通过成年人身高来解释。

鉴于在当代儿童中,超重发生率在增加,这些研究结果进一步强调了有效干预措施的必要性,以防止儿童超重。

原始出处:

Rebecca Hardy,et al.Birthweight, childhood growth and left ventricular structure at age 60–64 years in a British birth cohort study.Int. J. Epidemiol. first published online July 13, 2016

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    2016-10-23 jyzxjiangqin

    出生体重会影响晚年的左心室结构。

    0

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    2016-10-14 jyzxjiangqin

    这种说法不科学。

    0

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