Public Health Nutr:美国高危人群中产妇的产后血浆叶酸状态和早产之间的关系

2019-08-28 不详 网络

目的:虽然母体叶酸缺乏与神经管缺陷,贫血和低出生体重等不良妊娠结局有关,但在美国叶酸后强化时代背景下叶酸与早产(PTB)之间的关系尚无定论。本研究旨在探究母体叶酸状态与PTB及其亚型(即自发和医学指征的PTB)之间的关系。设计:观察性研究。设置:波士顿出生队列,主要是城市,低收入,种族/少数民族,PTB的风险很高的人群。参加者:参加波士顿出生队列的母婴双胞胎(n = 7675)。其中2313对双胞


目的:
虽然母体叶酸缺乏与神经管缺陷,贫血和低出生体重等不良妊娠结局有关,但在美国叶酸后强化时代背景下叶酸与早产(PTB)之间的关系尚无定论。本研究旨在探究母体叶酸状态与PTB及其亚型(即自发和医学指征的PTB)之间的关系。

设计:
观察性研究。

设置:
波士顿出生队列,主要是城市,低收入,种族/少数民族,PTB的风险很高的人群。

参加者:
参加波士顿出生队列的母婴双胞胎(n = 7675)。其中2313对双胞胎的母体分娩24-72小时后收集的母体血浆叶酸盐样品。

结果:
未经校正和校正后的逻辑回归显示,多种维生素补充剂摄入量与PTB之间存在反比关系。整个妊娠期间,与不常使用相比,多种维生素补充剂每周3-5次(校正OR(aOR)= 0.78; 95%CI 0.64,0.96)或> 5次/周(aOR =0.77; 95%CI 0.64,0.93)与PTB风险降低有关。一致地,较高的血浆叶酸水平(最高V. 最低四分位数)与较低的PTB风险相关(aOR =0.74; 95%CI 056,0.97)。上述关联在自发和医学指示的PTB中是相似的。

结论:
如果未来的研究证实,我们的研究结果提出了优化孕期孕妇叶酸水平可能有助于降低后叶酸强化时代高危美国人群中PTB的风险。

原始出处:

Olapeju B, Saifuddin A, et al., Maternal postpartum plasma folate status and preterm birth in a high-risk US population. Public Health Nutr. 2019 May;22(7):1281-1291. doi: 10.1017/S1368980018003221. Epub 2018 Nov 29.

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