Neurology:NMDAR脑炎患者1年预后预测评分

2018-12-26 zhangfan MedSci原创

功能状态(NEOS)评分对NMDAR脑炎患者1年预后具有极高的预测价值

近日研究人员就抗NMDA受体(NMDAR)脑炎诊断1年后神经功能的分级评分进行了考察。

382名患者参与研究,修正Rankin评分≥3的相关的因素纳入多因素逻辑回归模型,采用5分预测系统,考察抗NMDAR脑炎1年功能状态(NEOS)评分。

单变量研究发现,重症监护、治疗延迟>4周、4周内临床无改善、运动障碍、低通气、脑脊液白细胞计数升高、脑脊液蛋白水平升高和MRI异常与1年低功能评分相关。多变量分析发现,重症监护、治疗延迟>4周、MRI异常以及脑脊液白细胞计数高于20细胞/μL是独立的预后预测因素。NEOS得分对患者1年预后具有极高的预测价值,0-1分患者不良预后的风险为3%,而4-5分患者的风险则高达69%。

研究发现,功能状态(NEOS)评分对NMDAR脑炎患者1年预后具有极高的预测价值。

原始出处:


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    2019-08-20 wetgdt
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    2019-03-08 yinhl1978
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