ANN SURG ONCOL:乳腺癌切除术后乳房重建年龄或可延长

2013-01-07 Annals of Surgical Oncology dxy ecoliDH5

  选择接受乳腺癌切除术后乳房重建的各年龄段女性患者都认为,其生活质量因此而得到了改善。然而,乳房重建术的实际应用量却随着年龄增加而减少。该现象可能反映了患者的偏好以及某些临床因素,也可能为年龄相关不均一性的表现。对此,美国波士顿布莱根妇女医院Haejin In博士等人进行了一项研究,该研究发表于2012年12月22日在线出版的《外科肿瘤学年鉴》(Annals of Surgical Oncolo

  选择接受乳腺癌切除术后乳房重建的各年龄段女性患者都认为,其生活质量因此而得到了改善。然而,乳房重建术的实际应用量却随着年龄增加而减少。该现象可能反映了患者的偏好以及某些临床因素,也可能为年龄相关不均一性的表现。对此,美国波士顿布莱根妇女医院Haejin In博士等人进行了一项研究,该研究发表于2012年12月22日在线出版的《外科肿瘤学年鉴》(Annals of Surgical Oncology)杂志上。

  研究人员通过SEER医疗保险数据库,对65岁及以上的女性患者进行了甄别,这些患者均曾因DCIS/I期/II期乳腺癌(2000年-2005年)而接受 了乳房切除术。研究人员对总乳房重建率以及各医疗机构进行乳房重建的比例进行了测算。他们还对较高以及较低乳房重建率的医院特征进行了对比。最后通过患者 水平的逻辑回归模型,利用伪R2统计方法对机构以及患者特征的相对贡献量进行了估计。

  该项研究共对716家医疗机构的19234例患者进行了考察。研究人员发现,整体而言,在接受乳房切除术后,有6%的老年患者选择了乳房重建。各机构进行乳房重建比例的浮动范围为0至>40 %。尽管53 %的机构并不对老年患者进行乳房重建,但仍有5.6 %的机构其乳房重建率大于20%。此外,尽管患者特征(%ΔR2= 70 %),尤其是年龄(%ΔR2= 34 %)为进行乳房重建的主要决定因素,但通过解读,机构特征仍存在某些变异(%ΔR2= 16 %)。这表明,除了包括临床特征及患者偏好在内的适当的因素外,老年女性进行乳房重建也受到接受治疗机构的影响。

  因此,研究人员认为,医疗机构进行乳房重建的可能性存在着变异,相关结构特征表明,在乳腺癌治疗中的该关键手术方面,存在着获取机会的不均一性。因此,他们建议,应加强在年龄方面存在潜在不均一性的认识,对于渴望进行乳房重建的候选老年患者,这是提高她们获得治疗机会的首要步骤。 



Variation in the Utilization of Reconstruction Following Mastectomy in Elderly Women
Background
Regardless of their age, women who choose to undergo postmastectomy reconstruction report improved quality of life as a result. However, actual use of reconstruction decreases with increasing age. Whereas this may reflect patient preference and clinical factors, it may also represent age-based disparity.
Methods
Women aged 65 years or older who underwent mastectomy for DCIS/stage I/II breast cancer (2000–2005) were identified in the SEER-Medicare database. Overall and institutional rates of reconstruction were calculated. Characteristics of hospitals with higher and lower rates of reconstruction were compared. Pseudo-R² statistics utilizing a patient-level logistic regression model estimated the relative contribution of institution and patient characteristics.
Results
A total of 19,234 patients at 716 institutions were examined. Overall, 6 % of elderly patients received reconstruction after mastectomy. Institutional rates ranged from zero to >40 %. Whereas 53 % of institutions performed no reconstruction on elderly patients, 5.6 % performed reconstructions on more than 20 %. Although patient characteristics (%ΔR² = 70 %), and especially age (%ΔR² = 34 %), were the primary determinants of reconstruction, institutional characteristics also explained some of the variation (%ΔR² = 16 %). This suggests that in addition to appropriate factors, including clinical characteristics and patient preferences, the use of reconstruction among older women also is influenced by the institution at which they receive care.
Conclusions
Variation in the likelihood of reconstruction by institution and the association with structural characteristics suggests unequal access to this critical component of breast cancer care. Increased awareness of a potential age disparity is an important first step to improve access for elderly women who are candidates and desire reconstruction.                 

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    2013-11-07 minlingfeng