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PloS Pathogens：研究模拟HIV-抗体相互作用，优化HIV治疗！

2017-05-05 枫丹白露 来宝网

模拟HIV抗体HIV-1
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实验和数学分析揭示了HIV-1和抗体之间相互作用的新见解，可以抑制病毒从一个人传播到另一个人。在PLOS病原体中提出的这些发现可能有助于开发用于HIV-1的新的治疗方法和疫苗。

实验和数学分析揭示了HIV-1和抗体之间相互作用的新见解，可以抑制病毒从一个人传播到另一个人。在PLOS病原体中提出的这些发现可能有助于开发用于HIV-1的新的治疗方法和疫苗。

在瑞士苏黎世大学亚历山德拉·特拉科拉（Alexandra Trkola）工作的Oliver Brandenberg和Carsten Magnus进行了新的分析，大量证据表明某些可以靶向针对有害入侵者的抗体 - 免疫系统蛋白，具有对抗HIV-1的保护作用。尽管有这些证据，抗体和HIV-1之间相互作用的定量细节尚不清楚。

为了更好地了解这种相互作用，Trkola的团队首先对HIV-1和所讨论的抗体进行实验室实验，称为中和抗体（nAbs）。以前的研究表明，nAb与嵌入病毒外膜的蛋白质结合，防止这些蛋白质起到帮助HIV-1侵入宿主细胞的作用。

每个包膜蛋白最多可以结合三个抗体分子，但是新的实验表明只有一种抗体具有足以阻断包膜蛋白的功能。这个结果与每个病毒的包膜蛋白数量和进入细胞所需的数量相结合，使科学家能够利用数学模拟实验室和动物中中和HIV-1所需的nAb的量。

研究人员利用他们的新模型分析了以前对猕猴进行的研究结果，以估计单个HIV-1病毒可能在新宿主中引发感染的可能性。该团队还能够模拟在男性与女性之间传播的人类nAb-HIV-1相互作用模型，并预测单次性行为期间传播的机会以及预防感染所需的nAb浓度。

这些发现可以帮助研究基于nAb的疫苗和治疗，这已被证明是复杂的。全世界有数百万人感染艾滋病毒1，导致艾滋病。虽然抗逆转录病毒治疗使许多感染者能够延长寿命，但用疫苗治疗或预防是一个有吸引力的潜在替代方案。

作者解释说：“我们的研究强调了将理论和实验方法联系起来，以分解中和抗HIV-1传播抗体的保护作用和传播过程本身的细节。 “建立在我们的建模方法上，应尝试对被动免疫研究中的抗体功效进行事后和预处理建模分析，以最大限度地提高治疗效果。

原始出处：

Oliver F. Brandenberg, et al. Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters. PloS Pathogens.Published: May 4, 2017https://doi.org/10.1371/journal.ppat.1006313

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    2017-12-25 cnxcy

    #Pathogens#

    0

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    2018-03-10 medscijoin

    #相互作用#

    0

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    2017-06-12 海之蓝

    谢谢你哈

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1786122, encodeId=d0071e861220c, content=<a href='/topic/show?id=e30813e89e2' target=_blank style='color:#2F92EE;'>#Pathogens#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13789, encryptionId=e30813e89e2, topicName=Pathogens)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Mon Dec 25 09:38:00 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909201, encodeId=77f319092011f, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Sat Mar 10 08:38:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209840, encodeId=684720984028, content=谢谢你哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Mon Jun 12 13:42:03 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195867, encodeId=ce6c19586e0b, content=免疫是热点，研究东西多, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue May 09 16:46:25 CST 2017, time=2017-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471533, encodeId=ce5d14e15335a, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sun May 07 03:38:00 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194238, encodeId=482b194238a0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Fri May 05 18:48:29 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194202, encodeId=1f2919420290, content=免疫领域总是有很多东西可以做！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Fri May 05 14:43:53 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194188, encodeId=271819418822, content=学习了……不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Fri May 05 13:48:15 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-09 I come

    免疫是热点，研究东西多

    0

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    2017-05-07 ylz8405

    #互作#

    0

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    2017-05-05 衣带渐宽

    学习

    0

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    2017-05-05 184****9840

    免疫领域总是有很多东西可以做！

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1786122, encodeId=d0071e861220c, content=<a href='/topic/show?id=e30813e89e2' target=_blank style='color:#2F92EE;'>#Pathogens#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13789, encryptionId=e30813e89e2, topicName=Pathogens)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Mon Dec 25 09:38:00 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909201, encodeId=77f319092011f, content=<a href='/topic/show?id=8039e2512e8' target=_blank style='color:#2F92EE;'>#相互作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72512, encryptionId=8039e2512e8, topicName=相互作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f73a255, createdName=medscijoin, createdTime=Sat Mar 10 08:38:00 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209840, encodeId=684720984028, content=谢谢你哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Mon Jun 12 13:42:03 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195867, encodeId=ce6c19586e0b, content=免疫是热点，研究东西多, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Tue May 09 16:46:25 CST 2017, time=2017-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471533, encodeId=ce5d14e15335a, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Sun May 07 03:38:00 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194238, encodeId=482b194238a0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Fri May 05 18:48:29 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194202, encodeId=1f2919420290, content=免疫领域总是有很多东西可以做！, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Fri May 05 14:43:53 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194188, encodeId=271819418822, content=学习了……不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Fri May 05 13:48:15 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-05 尹玉伟

    学习了……不错

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