Stroke:卒中前危险因素可严重影响复发性卒中和卒中后痴呆症

2016-07-15 MedSci MedSci原创

改善卒中后短期生存,有必要量化卒中后(即复发性卒中和痴呆)的长期后遗症的风险和危险因素。这种风险可能会受到初发卒中暴露于心血管危险因素的影响。在基于人群的Rotterdam研究中,研究人员确定了卒中复发和老年痴呆症的长期风险,以及由于卒中前的心血管危险因素(即人群归因危险度)引起的复发性卒中和卒中后痴呆症比例。研究人员随访了1237例首次卒中患者和4928名无卒中的参与者,为卒中或痴呆发生匹配了年

改善卒中后短期生存,有必要量化卒中后(即复发性卒中和痴呆)的长期后遗症的风险和危险因素。这种风险可能会受到初发卒中暴露于心血管危险因素的影响。在基于人群的Rotterdam研究中,研究人员确定了卒中复发和老年痴呆症的长期风险,以及由于卒中前的心血管危险因素(即人群归因危险度)引起的复发性卒中和卒中后痴呆症比例。

研究人员随访了1237例首次卒中患者和4928名无卒中的参与者,为卒中或痴呆发生匹配了年龄,性别,检查周期和卒中日期(指数日期)。研究人员计算了这两个群体的发病率,并估计了个别和合并人群两个结果的卒中前危险因素的归因危险度。

卒中后1年,与无卒中人群相比,患者卒中复发风险增加3倍,老年痴呆症的风险几乎增加2倍。总的来说,39%(95%置信区间,18%-66%)的复发性卒中和10%(95%置信区间,0%-91%)的卒中后痴呆病例可归因于卒中前心血管疾病危险因素的暴露。这些百分比在匹配的无卒中人群中对于首次卒中和痴呆症是相似的。

复发性卒中和卒中后痴呆症的长期风险依然很高,并受到卒中前危险因素实质性的影响,这也强调了优化一级预防的必要性。

原始出处:

Marileen L.P. Portegies,Frank J. Wolters,Albert Hofman,et al.Prestroke Vascular Pathology and the Risk of Recurrent Stroke and Poststroke Dementia,Stroke,2016.7.14

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    2017-04-14 Boyinsh
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    2016-10-11 ylzr123

    赞了,认真探究、学习。

    0

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