JAMA Intern Med:冠状动脉无创造影与非缺血性胸痛

2017-06-27 zhangfan MedSci原创

研究表明非缺血性胸痛患者进行心脏测试会增加患者下游二次检测率,且该类患者的急性心肌梗死风险较低。该研究结果认为对于符合非缺血性胸痛的患者冠状动脉无创造影是不必要的。

冠状动脉无创造影是急救部门(ED)评估胸部疼痛患者的常规手段,但其对患者结果的影响尚不清楚。近日研究人员就心血管无创成像检测对急诊非缺血性胸痛患者的急性心肌梗死(AMI)发生率的影响开展了研究。

研究包含了2011-12年间,926633名18-64岁急诊非缺血性胸痛患者资料,考察无创性检查后患者2天或30天的病情变化。主要终点是无创测试与二次测试--冠状动脉血管造影术或冠状动脉血运重建术(经皮冠状动脉介入治疗或冠状动脉旁路移植术)以及7,30,180或365天AMI住院之间的关系。

患者平均年龄44.4岁,57.9%为女性。共224973名患者接受了无创测试,相比于未接受测试的患者(n=701660),其基线以及30天内AMI入院风险小幅提高(0.35% vs 0.14%)。工作日以及周末入院患者并发症率相近但工作日入院患者接受无创测试率增加。多因素调整后,30天内的无创测试显著提高冠状动脉血管造影术率(每1000名患者36,5人,95% CI,21.0-52.0)以及血管再造率(每1000患者22.8 人; 95% CI,10.6-35.0)但不影响AMI入院率(每1000患者7.8人,95% CI,-1.4- 17.0)。2天内的无创测试也会增加冠状动脉重建术率但不影响AMI入院率。

研究表明非缺血性胸痛患者进行心脏测试会增加患者下游二次检测率,且该类患者的急性心肌梗死风险较低。该研究结果认为对于符合非缺血性胸痛的患者冠状动脉无创造影是不必要的。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1892891, encodeId=2560189289172, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Aug 20 19:15:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217191, encodeId=143621e1910b, content=学习了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e291719269, createdName=大旺旺, createdTime=Fri Jun 30 22:04:11 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494034, encodeId=a257149403460, content=<a href='/topic/show?id=3e34949e333' target=_blank style='color:#2F92EE;'>#造影#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94973, encryptionId=3e34949e333, topicName=造影)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Thu Jun 29 05:15:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607727, encodeId=4de2160e727cb, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Jun 29 05:15:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215999, encodeId=9978215999bb, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue Jun 27 14:25:26 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-30 大旺旺

    学习了啊

    0

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    2017-06-29 sodoo
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    2017-06-27 131****1460

    学习了受益匪浅。

    0