NRR:人参皂苷Rb1防治脑缺血后神经元损伤的临床价值

2014-04-11 EurekAlert EurekAlert

脑缺血缺氧时,活化态小胶质细胞介导的炎症反应促进了神经元损伤。因此,寻找能抑制活化的小胶质细胞介导的神经元损伤的药物,是当前防治缺血缺氧性脑病研究领域亟待解决的热点问题之一。 由柯荔宁博士所在的中国南方医科大学和福建医科大学研究人员构成的联合研究团队,应用小胶质细胞与神经元共培养,并加入中国传统中药人参皂苷作为药物干预手段。可靠的结果证明人参皂苷Rb1可能通过下调缺氧活化的小胶质细胞中的一氧化氮

脑缺血缺氧时,活化态小胶质细胞介导的炎症反应促进了神经元损伤。因此,寻找能抑制活化的小胶质细胞介导的神经元损伤的药物,是当前防治缺血缺氧性脑病研究领域亟待解决的热点问题之一。

由柯荔宁博士所在的中国南方医科大学和福建医科大学研究人员构成的联合研究团队,应用小胶质细胞与神经元共培养,并加入中国传统中药人参皂苷作为药物干预手段。可靠的结果证明人参皂苷Rb1可能通过下调缺氧活化的小胶质细胞中的一氧化氮、O2-、和肿瘤坏死因子α的表达减轻大脑皮质神经元的损伤。

这些发现提示人参皂苷Rb1有望成为临床上防治脑缺血后神经元功能退行性变的有效措施,具有潜在的临床应用价值。相关研究发表于《中国神经再生研究(英文版)》杂志2014年2月第3期。

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