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Thyroid：孕妇亚甲减对妊娠结局危害多

2016-02-18 Mechront 译 MedSci原创

亚临床甲减妊娠孕妇
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目前关于孕妇亚临床甲减 (SCH) 和左旋甲状腺素替代治疗对妊娠结局的影响仍不明确，因此研究者检索了MEDLINE、EMBASE等数据库，获取相关文献矜持系统回顾和荟萃分析，以评估孕期SCH和左旋甲状腺素替代治疗对妊娠结局的影响。最终共纳入了18篇研究，研究数据显示，与甲工正常的孕妇相比，SCH孕妇有更高的妊娠丢失风险 (RR 2.01, CI 1.66 to 2.44)、胎盘破裂风险(RR 2.

目前关于孕妇亚临床甲减 (SCH) 和左旋甲状腺素替代治疗对妊娠结局的影响仍不明确，因此研究者检索了MEDLINE、EMBASE等数据库，获取相关文献进行系统回顾和荟萃分析，以评估孕期SCH和左旋甲状腺素替代治疗对妊娠结局的影响。

最终共纳入了18篇研究，研究数据显示，与甲状腺功能正常的孕妇相比，SCH孕妇有更高的妊娠丢失风险 (RR 2.01, CI 1.66 to 2.44)、胎盘破裂风险(RR 2.14, CI 1.23 to 3.70)、未足月胎膜早破风险(RR 1.43, CI 1.04 to 1.95)和新生儿死亡风险(RR 2.58, CI 1.41 to 4.73)。一篇偏倚较高的关于接受左旋甲状腺素替代治疗的SCH孕妇妊娠结局的研究，没有发现左旋甲状腺素替代治疗会显著降低妊娠丢失、早产、妊娠期高血压、低出生体重儿和低Apgar评分风险。

研究看结果表明，孕期SCH会导致多种不良母儿妊娠结局的风险增加，而左旋甲状腺素替代治疗对预防这些不良结局的影响目前仍不明确。

原始出处：

Maraka S, Singh Ospina NM,et al.Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-analysis.Thyroid. 2016 Feb 3. 


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    2016-05-31 明崖

    不错的研究

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=87931, encodeId=88c48e9318e, content=不错的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Tue May 31 21:44:00 CST 2016, time=2016-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=72486, encodeId=f5bbe2486d7, content=需要补充甲状腺素片, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Mon Mar 21 23:54:00 CST 2016, time=2016-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66178, encodeId=239d661e811, content=嗯嗯, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sun Feb 28 15:26:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66179, encodeId=f973661e997, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19691629579, createdName=zm0805, createdTime=Sun Feb 28 15:26:00 CST 2016, time=2016-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1341299, encodeId=4f111341299ba, content=<a href='/topic/show?id=0cb769e593b' target=_blank style='color:#2F92EE;'>#甲减#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69759, encryptionId=0cb769e593b, topicName=甲减)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sat Feb 20 13:31:00 CST 2016, time=2016-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392911, encodeId=ae7a139291195, content=<a href='/topic/show?id=8c9f4492370' target=_blank style='color:#2F92EE;'>#妊娠结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44923, encryptionId=8c9f4492370, topicName=妊娠结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fa82500120, createdName=12498a1cm67暂无昵称, createdTime=Sat Feb 20 13:31:00 CST 2016, time=2016-02-20, status=1, ipAttribution=)]
    2016-03-21 Gsurgeon

    需要补充甲状腺素片

    0

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    2016-02-28 zm0805

    嗯嗯

    0

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    2016-02-28 zm0805

    牛

    0

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    2016-02-20 12498cf9m35(暂无昵称)

    #甲减#

    0

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    2016-02-20 12498a1cm67暂无昵称

    #妊娠结局#

    0