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Int J Nanomed：氧化物纳米粒子的抗菌活性如何

2018-01-27 MedSci MedSci原创

关注

致病菌对抗生素耐药性的增加是一个全球性的难题，亟需寻找新的更有效的抗菌药物。研究已发现纳米技术对抗细菌的有效工具。 利用X射线衍射、高分辨率透射电子显微镜和能量色散X射线光谱仪对三金属（CuZnFe）氧化物纳米粒子（NPs）进行表征。此外，研究人员还评估了这些NPs对革兰氏阴性大肠杆菌和革兰氏阳性粪肠球菌的抗菌活性，然后将其与纯单一金属氧化物组分CuO和ZnO进行比较。 结果显示，三氧化二铁纳米粒

致病菌对抗生素耐药性的增加是一个全球性的难题，亟需寻找新的更有效的抗菌药物。研究已发现纳米技术对抗细菌的有效工具。

利用X射线衍射、高分辨率透射电子显微镜和能量色散X射线光谱仪对三金属（CuZnFe）氧化物纳米粒子（NPs）进行表征。此外，研究人员还评估了这些NPs对革兰氏阴性大肠杆菌和革兰氏阳性粪肠球菌的抗菌活性，然后将其与纯单一金属氧化物组分CuO和ZnO进行比较。

结果显示，三氧化二铁纳米粒子对大肠杆菌的抗菌活性较粪肠球菌更大。总体来说，三金属纳米粒子的抗菌效果处于纯ZnO和CuO纳米粒子之间，这可能意味着它们的细胞毒性也介于纯ZnO和CuO纳米粒子之间，使其成为潜在的抗生素。然而，三价金属纳米粒子对哺乳动物细胞的细胞毒性仍需要验证。

综上所述，该研究结果表明，组合ZnO、CuO和Fe2O3的三金属（CuZnFe）氧化物纳米粒子将增强对各种微生物的感染。而且细菌不太可能对这种新的NPs产生抗性，因为细菌必须经历一系列突变以变得对三金属氧化物纳米粒子有抗性。因此，这个纳米粒子可以抵抗现有和新出现的细菌感染。

原始出处：

Alzahrani KE, Niazy AA, et al., Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles. Int J Nanomedicine. 2017 Dec 20;13:77-87. doi: 10.2147/IJN.S154218. eCollection 2018.

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    2018-11-08 zjubiostat

    #纳米粒#

    0

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    2018-02-12 天涯183

    非常好的文章.学习了.很收益

    0

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    2018-02-04 天涯183

    非常好的文章.学习了

    0

  4. 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    2018-01-29 ms7899726347904398

    #抗菌#

    0

  5. 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    2018-01-29 xre2012

    #抗菌活性#

    0

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createdTime=Sun Jan 28 06:31:31 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282718, encodeId=6db7282e18a3, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jan 28 00:28:24 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-29 ms920641618706883

    #纳米粒子#

    0

  7. 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topicName=抗菌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Mon Jan 29 12:12:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538715, encodeId=10a81538e1577, content=<a href='/topic/show?id=35fa55e03ee' target=_blank style='color:#2F92EE;'>#抗菌活性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55703, encryptionId=35fa55e03ee, topicName=抗菌活性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fe6d13029843, createdName=xre2012, createdTime=Mon Jan 29 12:12:00 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580625, encodeId=ec85158062549, content=<a href='/topic/show?id=d4c6e7430be' target=_blank 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283059, encodeId=6eef28305979, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jan 29 04:57:12 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282752, encodeId=6165282e525b, content=抗感染是临床工作中的困难, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Jan 28 06:31:31 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282718, encodeId=6db7282e18a3, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jan 28 00:28:24 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-29 ms3994565386320060

    #Med#

    0

  8. 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    2018-01-29 三生有幸9135

    学习一下谢谢分享

    0

  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=283059, encodeId=6eef28305979, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Jan 29 04:57:12 CST 2018, time=2018-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282752, encodeId=6165282e525b, content=抗感染是临床工作中的困难, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sun Jan 28 06:31:31 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282718, encodeId=6db7282e18a3, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jan 28 00:28:24 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-28 秀红

    抗感染是临床工作中的困难

    0

  10. 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createdTime=Sun Jan 28 06:31:31 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282718, encodeId=6db7282e18a3, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sun Jan 28 00:28:24 CST 2018, time=2018-01-28, status=1, ipAttribution=)]
    2018-01-28 飛歌

    厉害了我的哥

    0

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