J Periodontol:牙周治疗的微生物学和临床结果的多变量预测

2017-11-23 MedSci MedSci原创

本研究评估了两阶段抗菌牙周治疗的微生物学效应,并检测作为临床预后指标的微生物学,临床和生物学指标。

本研究评估了两阶段抗菌牙周治疗的微生物学效应,并检测作为临床预后指标的微生物学,临床和生物学指标。

方法:80例慢性或侵袭性牙周炎患者接受牙周治疗,辅以375mg阿莫西林加500mg甲硝唑,每日3次,服用7天。 A组在第一次非手术阶段(T1)给予抗生素治疗。 B组在第二次手术阶段(T2)给予抗生素治疗。评估术后12个月时血清中6种微生物,组别,人口统计学和临床变量,15种细胞因子的峰值和9种血清急性期蛋白质作为潜在预测因子,检测至少一个位点的探诊深度(PD> 4mm)和探诊出血(BOP)。

结果:T1阶段A组的牙龈卟啉单胞菌,福赛斯坦纳菌,中间普氏菌(Pi)和密螺旋体的下降明显多于B组。只有辅助服用抗生素时,伴放线放线杆菌和微小单细胞菌(PM)才会明显减少,即A组中的T1或B组中的T2。T2后,组间差异不再明显。包括四个参数的多变量模型表明,Pm(比值比[OR] = 4.38,P = 0.02)和Pi(OR = 3.44,P = 0.049)的预测值并且对于预测治疗结果的中度准确性(曲线下面积= 0.72)。宿主源性因素和治疗顺序与结果没有显着相关性。

长期的微生物学结果与抗生素应用时间无明显关系。治疗前Pm的检测可用作治疗12个月后持续存在PD> 4mm和BOP位点的预测因子。

原始出处:

Andrea Mombelli, et al. Microbiologic Response to Periodontal Therapy and Multivariable Prediction of Clinical Outcome. Journal of Periodontology . 2017 December. doi: 10.1902/jop.2017.170286

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  8. 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level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Nov 24 07:15:54 CST 2017, time=2017-11-24, status=1, ipAttribution=)]
    2017-11-24 1e1b8538m79(暂无匿称)

    不错的文章值得推荐

    0

  9. 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    2017-11-24 Y—xianghai

    学习了新知识

    0

  10. 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level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Nov 24 07:15:54 CST 2017, time=2017-11-24, status=1, ipAttribution=)]
    2017-11-24 明月清辉

    谢谢分享.学习了

    0

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