ASO:腹腔镜胃切除治疗胃间质瘤短期结局优于开腹胃切除

2013-07-11 ecoliDH5 dxy

在2013年6月21日在线出版的《外科肿瘤学年鉴》(Annals of Surgical Oncology)杂志上,发表了新加坡杜克国立大学医学研究生院Brian K. P. Goh教授等人的一项研究结果,该研究通过系统性考察及荟萃分析,对腹腔镜胃切除术(LR)及开腹胃切除术(OR)在胃间质瘤(GIST)治疗的短期和长期结局进行了对比。该文针对对比考察LR和OR治疗GIST的相关研究报告进行了考察

在2013年6月21日在线出版的《外科肿瘤学年鉴》(Annals of Surgical Oncology)杂志上,发表了新加坡杜克国立大学医学研究生院Brian K. P. Goh教授等人的一项研究结果,该研究通过系统性考察及荟萃分析,对腹腔镜胃切除术(LR)及开腹胃切除术(OR)在胃间质瘤(GIST)治疗的短期和长期结局进行了对比。该文针对对比考察LR和OR治疗GIST的相关研究报告进行了考察。该研究发现,与OR相比,LR在术后短期结局方面具有优势,且LR在肿瘤学安全性及长期肿瘤学结局方面也不逊于OR。

这项研究共包括11项非随机研究中的765例患者:其中381例LR患者,384 例OR患者。与LR患者相比,OR患者高危肿瘤及胃切除比例较高(风险比, 3.348; 95 % CI, 1.248-8.983; p = .016)及 (风险比, .169; 95 % CI, .090-.315; p < .001)。LR组患者术中失血量明显较低[加权均数差 (WMD), -86.508 ml; 95 % CI, -141.184 至 -31.831 ml; p < .002]。LR组与明显较低的轻微并发症风险(风险比, .517; 95 % CI, .277-.965; p = .038)、较短的术后住院期(WMD, -3.421 天; 95 % CI, -4.737至 -2.104天; p < .001)、较短的首次肠胃排气时间(WMD, -1.395天; 95 % CI, -1.655 至-1.135 天; p < .001)及较短的口腔摄食时间(WMD, -1.887 天; 95 % CI, -2.785 至 -.989天; p < .001)有关。两组间在手术时间(WMD, 5.731 min; 95 % CI, -15.354-26.815 min; p = .594)、阳性切缘(风险比,.501; 95 % CI, .157-1.603; p = .244)、局部复发率(风险比, .629; 95 % CI, .208-1.903; p = .412)、无复发生存率(RFS) (风险比, 1.28; 95 % CI, .705-2.325; p = .417)及总生存率(OS) (风险比, 1.879; 95 % CI, .591-5.979; p = .285)方面并无统计学意义上的显著差异。


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    2014-01-31 huangdf
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2080750, encodeId=e0e02080e5007, content=<a href='/topic/show?id=236d4968367' target=_blank style='color:#2F92EE;'>#开腹胃切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49683, encryptionId=236d4968367, topicName=开腹胃切除)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Feb 21 12:27:00 CST 2014, time=2014-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705275, encodeId=aedc1e05275dc, content=<a href='/topic/show?id=89f7e321268' target=_blank style='color:#2F92EE;'>#短期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73212, encryptionId=89f7e321268, topicName=短期结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=050630964579, createdName=fengyi822, createdTime=Tue Jun 10 23:27:00 CST 2014, time=2014-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1913745, encodeId=6d261913e4533, content=<a href='/topic/show?id=6f5328e398' target=_blank style='color:#2F92EE;'>#ASO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2873, encryptionId=6f5328e398, topicName=ASO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Fri Jan 31 20:27:00 CST 2014, time=2014-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276321, encodeId=185f12e6321ac, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sat Jul 13 05:27:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425981, encodeId=fb631425981f1, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Sat Jul 13 05:27:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518557, encodeId=ceb1151855e67, content=<a href='/topic/show?id=324183166ad' target=_blank style='color:#2F92EE;'>#胃切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83166, encryptionId=324183166ad, topicName=胃切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3cc11160823, createdName=bshuang, createdTime=Sat Jul 13 05:27:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615362, encodeId=d9e016153628a, content=<a href='/topic/show?id=d6128339573' target=_blank style='color:#2F92EE;'>#胃间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83395, encryptionId=d6128339573, topicName=胃间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d54019619450, createdName=ms920641618706883, createdTime=Sat Jul 13 05:27:00 CST 2013, time=2013-07-13, status=1, ipAttribution=)]
    2013-07-13 bshuang
  7. [GetPortalCommentsPageByObjectIdResponse(id=2080750, encodeId=e0e02080e5007, content=<a href='/topic/show?id=236d4968367' target=_blank style='color:#2F92EE;'>#开腹胃切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49683, encryptionId=236d4968367, topicName=开腹胃切除)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Feb 21 12:27:00 CST 2014, time=2014-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705275, encodeId=aedc1e05275dc, content=<a href='/topic/show?id=89f7e321268' target=_blank style='color:#2F92EE;'>#短期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73212, encryptionId=89f7e321268, topicName=短期结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=050630964579, createdName=fengyi822, createdTime=Tue Jun 10 23:27:00 CST 2014, time=2014-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1913745, encodeId=6d261913e4533, content=<a href='/topic/show?id=6f5328e398' target=_blank style='color:#2F92EE;'>#ASO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2873, encryptionId=6f5328e398, topicName=ASO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2e0330, createdName=huangdf, createdTime=Fri Jan 31 20:27:00 CST 2014, time=2014-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276321, encodeId=185f12e6321ac, content=<a href='/topic/show?id=768685612db' target=_blank style='color:#2F92EE;'>#腹腔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85612, encryptionId=768685612db, topicName=腹腔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Sat Jul 13 05:27:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425981, encodeId=fb631425981f1, content=<a href='/topic/show?id=02fe9e30227' target=_blank style='color:#2F92EE;'>#间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97302, encryptionId=02fe9e30227, topicName=间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ede4029724, createdName=zhty5338, createdTime=Sat Jul 13 05:27:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518557, encodeId=ceb1151855e67, content=<a href='/topic/show?id=324183166ad' target=_blank style='color:#2F92EE;'>#胃切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83166, encryptionId=324183166ad, topicName=胃切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3cc11160823, createdName=bshuang, createdTime=Sat Jul 13 05:27:00 CST 2013, time=2013-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615362, encodeId=d9e016153628a, content=<a href='/topic/show?id=d6128339573' target=_blank style='color:#2F92EE;'>#胃间质瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83395, encryptionId=d6128339573, topicName=胃间质瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d54019619450, createdName=ms920641618706883, createdTime=Sat Jul 13 05:27:00 CST 2013, time=2013-07-13, status=1, ipAttribution=)]