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J Clin Periodontol: rhBMP-2/ACS在上颌窦增强中的作用

2018-08-19 MedSci MedSci原创

rhBMP-2/ACS上颌窦种植
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已知，可吸收胶原海绵载体（rhBMP-2 / ACS）中的重组人骨形态发生蛋白-2可用于骨形成，以增强上颌窦支持种植。然而，骨生物材料被认为可延伸rhBMP-2 / ACS，这些方法的优点有限。实验使用小猪窦增强模型，模型内植入rhBMP-2 / ACS与陶瓷骨生物材料结合物后评估局部骨形成/种植体骨整合。

已知，可吸收胶原海绵载体（rhBMP-2 / ACS）中的重组人骨形态发生蛋白-2可用于骨形成，以增强上颌窦支持种植。然而，骨生物材料被认为可延伸rhBMP-2 / ACS，这些方法的优点有限。实验使用小猪窦增强模型，模型内植入rhBMP-2 / ACS与陶瓷骨生物材料结合物后评估局部骨形成/种植体骨整合。

方法：12只成年G？ttingen小型猪单独接受rhBMP-2 / ACS（rhBMP-2调整至0.43 mg / cc）或与双相陶瓷（15％/ 85％HA /？-TCP）生物材料结合使用（3：1，1：1和1：3比率）于对侧上颌窦部位，rhBMP-2 / ACS比例分别为100％，75％，50％和25％的。所有部位均使用4-cc植入体积。在每个部位放置两个螺纹种植体（？4.0×11.5 mm）。在第8周对动物施行安乐死，并进行组织学分析。

结果：手术和愈合通常是平稳的，在所有动物中均观察到眶下局部肿胀，直到缝线拆除。与单独的rhBMP-2 / ACS（8.6±1.1 mm； p> 0.05）相比，rhBMP-2 / ACS与陶瓷生物材料相结合并未显着增强局部骨形成（范围9.0±1.5至9.7±2.1 mm）。 rhBMP-2 / ACS与陶瓷基质比率的变化产生rhBMP-2剂量接近0.4，0.9，1.3和1.7mg /窦，但没有明显影响骨形成/骨整合。

rhBMP-2 / ACS在小型猪窦增强模型中有助于骨形成/骨整合，似乎是窦增强术的有效替代方案，但是rhBMP-2 / ACS结合陶瓷生物材料不会产生显着的生物学优势。

原始出处：

Cristiano Susin， et al. Sinus augmentation using rhBMP‐2/ACS in a mini‐pig model： Influence of an adjunctive ceramic bone biomaterial. Journal of Clinical Periodontology. 2018 August. doi： 10.1111/jcpe.12921

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    2019-04-16 12498f17m73暂无昵称

    #BMP-2#

    0

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    2019-02-18 ms5187542471278033

    #rhBMP#

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    2018-12-09 feather89

    #PE#

    0

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    2018-10-11 HNYYM

    #BMP#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1642656, encodeId=e80e16426560d, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Tue Apr 16 20:09:00 CST 2019, time=2019-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793337, encodeId=27b71e9333794, content=<a href='/topic/show?id=a38d15430ea' target=_blank style='color:#2F92EE;'>#rhBMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15430, encryptionId=a38d15430ea, topicName=rhBMP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Mon Feb 18 12:09:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727547, encodeId=b39f1e2754759, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Dec 09 08:09:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634042, encodeId=bf17163404239, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Thu Oct 11 10:09:00 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279277, encodeId=37e012e9277b3, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575276, encodeId=a8b215e52767d, content=<a href='/topic/show?id=0d3a20096d0' target=_blank style='color:#2F92EE;'>#上颌窦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20096, encryptionId=0d3a20096d0, topicName=上颌窦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4316082286, createdName=AspirantSuo, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631153, encodeId=092e163115361, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=)]
    2018-08-21 yaanren

    #ACS#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1642656, encodeId=e80e16426560d, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Tue Apr 16 20:09:00 CST 2019, time=2019-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793337, encodeId=27b71e9333794, content=<a href='/topic/show?id=a38d15430ea' target=_blank style='color:#2F92EE;'>#rhBMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15430, encryptionId=a38d15430ea, topicName=rhBMP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Mon Feb 18 12:09:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727547, encodeId=b39f1e2754759, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Dec 09 08:09:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634042, encodeId=bf17163404239, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Thu Oct 11 10:09:00 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279277, encodeId=37e012e9277b3, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575276, encodeId=a8b215e52767d, content=<a href='/topic/show?id=0d3a20096d0' target=_blank style='color:#2F92EE;'>#上颌窦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20096, encryptionId=0d3a20096d0, topicName=上颌窦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4316082286, createdName=AspirantSuo, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631153, encodeId=092e163115361, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=)]
    2018-08-21 AspirantSuo

    #上颌窦#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1642656, encodeId=e80e16426560d, content=<a href='/topic/show?id=814c35e6e2' target=_blank style='color:#2F92EE;'>#BMP-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3576, encryptionId=814c35e6e2, topicName=BMP-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=120c22999408, createdName=12498f17m73暂无昵称, createdTime=Tue Apr 16 20:09:00 CST 2019, time=2019-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1793337, encodeId=27b71e9333794, content=<a href='/topic/show?id=a38d15430ea' target=_blank style='color:#2F92EE;'>#rhBMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15430, encryptionId=a38d15430ea, topicName=rhBMP)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKUdkK5dVTue7YQDvwqM1ugOuEpDZEzvXhoGClFiavehcrNAYDuPbks3MkKLPpyAEicgic80KguxwicYQ/132, createdBy=ec952500165, createdName=ms5187542471278033, createdTime=Mon Feb 18 12:09:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727547, encodeId=b39f1e2754759, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Dec 09 08:09:00 CST 2018, time=2018-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634042, encodeId=bf17163404239, content=<a href='/topic/show?id=596635e549' target=_blank style='color:#2F92EE;'>#BMP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3575, encryptionId=596635e549, topicName=BMP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d95322064897, createdName=HNYYM, createdTime=Thu Oct 11 10:09:00 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279277, encodeId=37e012e9277b3, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575276, encodeId=a8b215e52767d, content=<a href='/topic/show?id=0d3a20096d0' target=_blank style='color:#2F92EE;'>#上颌窦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20096, encryptionId=0d3a20096d0, topicName=上颌窦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4316082286, createdName=AspirantSuo, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631153, encodeId=092e163115361, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Tue Aug 21 06:09:00 CST 2018, time=2018-08-21, status=1, ipAttribution=)]
    2018-08-21 hanhaisha2015

    #上颌#

    0