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PLOS Genetics：血脂代谢物早期识别心血管疾病

2014-12-26 佚名 生物谷

血脂代谢物心血管
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心血管疾病指的是威胁人类健康的最常见疾病，其发病率在中国居于首位。近日，一项科学研究发现一种新的循环代谢物可能有助心血管疾病的早期诊断。[pdf free]一队来自乌普萨拉大学，卡罗林斯卡研究所和科罗拉多州立大学的科学家已经确定了冠状动脉心脏疾病事件有关的新脂质衍生分子。相关研究已经发表在杂志PLOS Genetics上，研究审查了已随访长达10年的3600多人血样的代谢特性。新研究已确定了两个脂

心血管疾病指的是威胁人类健康的最常见疾病，其发病率在中国居于首位。近日，一项科学研究发现一种新的循环代谢物可能有助心血管疾病的早期诊断。[pdf free]

一队来自乌普萨拉大学，卡罗林斯卡研究所和科罗拉多州立大学的科学家已经确定了冠状动脉心脏疾病事件有关的新脂质衍生分子。

相关研究已经发表在杂志PLOS Genetics上，研究审查了已随访长达10年的3600多人血样的代谢特性。新研究已确定了两个脂质代谢产物——溶血卵磷脂和鞘磷脂与冠状心脏疾病风险减少有关。

另一个脂类代谢物即单酸甘油酯，发现与冠状动脉心脏疾病的风险增加有关。先前研究已经发现一些代谢物与冠状动脉心脏疾病相关的遗传变异有很强关联性。

上述研究结果结果在不同的随访时间内都被复制。这项研究表明，血脂代谢产物可能对未来心血管疾病的预测有用。

目前，研究人员正在开展体内实验调查这些代谢物对心血管疾病发展的潜在因果作用。如果得到证实，那么这些发现也可能指出新的治疗靶点。



原始出处：

Ganna A1, Salihovic S2, Sundström J2, Broeckling CD3, Hedman AK4, Magnusson PK1, Pedersen NL1, Larsson A5, Siegbahn A6, Zilmer M7, Prenni J8, Arnlöv J9, Lind L2, Fall T4, Ingelsson E10.Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease.PLoS Genet. 2014 Dec 11;10(12):e1004801. doi: 10.1371/journal.pgen.1004801. eCollection 2014.[pdf free]

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    2015-02-04 cy0324

    #Gene#

    0

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    2015-01-30 canlab

    #NET#

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    2015-07-18 旅苦化文_216

    #代谢物#

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    2015-08-09 huperzia

    #Genetics#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2048637, encodeId=b093204863ea9, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Wed Feb 04 19:28:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733728, encodeId=e8ee1e337285f, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Jan 30 03:28:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659943, encodeId=68f71659943b7, content=<a href='/topic/show?id=24e82545262' target=_blank style='color:#2F92EE;'>#代谢物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25452, encryptionId=24e82545262, topicName=代谢物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c1225086772, createdName=旅苦化文_216, createdTime=Sat Jul 18 15:28:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877948, encodeId=028418e7948ea, content=<a href='/topic/show?id=5d80e943ef' target=_blank style='color:#2F92EE;'>#Genetics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7943, encryptionId=5d80e943ef, topicName=Genetics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Aug 09 02:28:00 CST 2015, time=2015-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685979, encodeId=3a7116859e9e1, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Tue Dec 01 17:28:00 CST 2015, time=2015-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497858, encodeId=83bf149e85829, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Dec 28 05:28:00 CST 2014, time=2014-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597057, encodeId=dfee159e05749, content=<a href='/topic/show?id=e7f6842982d' target=_blank style='color:#2F92EE;'>#脂代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84298, encryptionId=e7f6842982d, topicName=脂代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce3218475330, createdName=huangdf, createdTime=Sun Dec 28 05:28:00 CST 2014, time=2014-12-28, status=1, ipAttribution=)]
    2015-12-01 江川靖瑶

    #Genet#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2048637, encodeId=b093204863ea9, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Wed Feb 04 19:28:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733728, encodeId=e8ee1e337285f, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Jan 30 03:28:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659943, encodeId=68f71659943b7, content=<a href='/topic/show?id=24e82545262' target=_blank style='color:#2F92EE;'>#代谢物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25452, encryptionId=24e82545262, topicName=代谢物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c1225086772, createdName=旅苦化文_216, createdTime=Sat Jul 18 15:28:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877948, encodeId=028418e7948ea, content=<a href='/topic/show?id=5d80e943ef' target=_blank style='color:#2F92EE;'>#Genetics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7943, encryptionId=5d80e943ef, topicName=Genetics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Aug 09 02:28:00 CST 2015, time=2015-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685979, encodeId=3a7116859e9e1, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Tue Dec 01 17:28:00 CST 2015, time=2015-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497858, encodeId=83bf149e85829, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Dec 28 05:28:00 CST 2014, time=2014-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597057, encodeId=dfee159e05749, content=<a href='/topic/show?id=e7f6842982d' target=_blank style='color:#2F92EE;'>#脂代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84298, encryptionId=e7f6842982d, topicName=脂代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce3218475330, createdName=huangdf, createdTime=Sun Dec 28 05:28:00 CST 2014, time=2014-12-28, status=1, ipAttribution=)]
    2014-12-28 andy2090

    #血管疾病#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2048637, encodeId=b093204863ea9, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Wed Feb 04 19:28:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733728, encodeId=e8ee1e337285f, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Jan 30 03:28:00 CST 2015, time=2015-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659943, encodeId=68f71659943b7, content=<a href='/topic/show?id=24e82545262' target=_blank style='color:#2F92EE;'>#代谢物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25452, encryptionId=24e82545262, topicName=代谢物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c1225086772, createdName=旅苦化文_216, createdTime=Sat Jul 18 15:28:00 CST 2015, time=2015-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877948, encodeId=028418e7948ea, content=<a href='/topic/show?id=5d80e943ef' target=_blank style='color:#2F92EE;'>#Genetics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7943, encryptionId=5d80e943ef, topicName=Genetics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Aug 09 02:28:00 CST 2015, time=2015-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685979, encodeId=3a7116859e9e1, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Tue Dec 01 17:28:00 CST 2015, time=2015-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497858, encodeId=83bf149e85829, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sun Dec 28 05:28:00 CST 2014, time=2014-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597057, encodeId=dfee159e05749, content=<a href='/topic/show?id=e7f6842982d' target=_blank style='color:#2F92EE;'>#脂代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84298, encryptionId=e7f6842982d, topicName=脂代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce3218475330, createdName=huangdf, createdTime=Sun Dec 28 05:28:00 CST 2014, time=2014-12-28, status=1, ipAttribution=)]
    2014-12-28 huangdf

    #脂代谢#

    0