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BMJ Open：血纤维蛋白原水平与心血管事件有关

2017-06-14 朱柳媛 中国循环杂志

血纤维蛋白原心血管
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阜外医院李建军教授等开展的一项前瞻性观察性研究显示，在我国合并2型糖尿病的稳定性冠心病患者中，血纤维蛋白原水平升高与心血管事件风险增加独立相关。 在单因素回归分析中，血纤维蛋白原水平每升高1个标准差，心血管事件风险增加25%。

阜外医院李建军教授等开展的一项前瞻性观察性研究显示，在我国合并2型糖尿病的稳定性冠心病患者中，血纤维蛋白原水平升高与心血管事件风险增加独立相关。在单因素回归分析中，血纤维蛋白原水平每升高1个标准差，心血管事件风险增加25%。校正多个已知的心血管病危险因素后，两者仍独立相关（HR=1.30， 95%CI：1.02~1.66， P=0.037）。校正已知的心血管病危险因素后，与血纤维蛋白原水平较低（≥2.91g/L）者相比，血纤维蛋白原水平处于中等水平（2.91~3.51g/L）和较高水平（≥3.51g/L）的患者发生心血管事件的风险分别增加23%和120%。该研究首次在合并2型糖尿病的稳定性冠心病患者中发现，血纤维蛋白原水平与心血管事件独立相关。研究者认为，尽管该研究随访期相对较短，但目前的数据表明，基线纤维蛋白原水平或许可以作为2型糖尿病合并冠心病患者临床结局的预测标志物。这项研究共纳入1466例合并2型糖尿病的稳定性冠心病患者。平均随访20.2个月，96例患者发生心血管事件。原始出处：Yang SH, Du Y, Zhang Y, et al. Serum fibrinogen an

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    2017-11-25 axin009

    #纤维蛋白#

    0

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    2018-03-16 hukaixun

    #血管事件#

    0

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    2017-07-01 gaoxiaoe

    #BMJ#

    0

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    2017-11-30 feather89

    #PE#

    0

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    2017-06-16 waiwai3030

    #纤维蛋白原#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1997238, encodeId=148b199e238e8, content=<a href='/topic/show?id=cc04e727535' target=_blank style='color:#2F92EE;'>#纤维蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77275, encryptionId=cc04e727535, topicName=纤维蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Sat Nov 25 09:03:00 CST 2017, time=2017-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643465, encodeId=0d291643465d3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Fri Mar 16 20:03:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848327, encodeId=5fb4184832eda, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Jul 01 17:03:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726473, encodeId=81e51e264735d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Nov 30 01:03:00 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362605, encodeId=1ba61362605b0, content=<a href='/topic/show?id=9f6ce72774d' target=_blank style='color:#2F92EE;'>#纤维蛋白原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77277, encryptionId=9f6ce72774d, topicName=纤维蛋白原)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Fri Jun 16 02:03:00 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210650, encodeId=774721065033, content=学习了，涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Jun 14 12:58:34 CST 2017, time=2017-06-14, status=1, ipAttribution=)]
    2017-06-14 1ddf0692m34(暂无匿称)

    学习了，涨知识

    0