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Front Microbiol：脂磷壁酸抑制金黄色葡萄球菌生物膜形成

2018-04-01 MedSci MedSci原创

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生物膜是细胞粘附于生物或非生物表面的微生物的聚集体，可引发各种传染病。金黄色葡萄球菌引起的感染，包括肺炎、心内膜炎和骨髓炎，通常与细菌定植和生物膜形成有关。尽管脂磷壁酸（LTA）参与生物膜形成，但LTA的具体作用尚不清楚。在这项研究中，我们证明从植物乳杆菌释放的LTA可以抑制金黄色葡萄球菌生物膜形成和聚集，而不影响金黄色葡萄球菌在各种体外和体内模型中的生长。植物乳杆菌LTA（Lp.LTA）也抑制金

生物膜是细胞粘附于生物或非生物表面的微生物的聚集体，可引发各种传染病。金黄色葡萄球菌引起的感染，包括肺炎、心内膜炎和骨髓炎，通常与细菌定植和生物膜形成有关。尽管脂磷壁酸（LTA）参与生物膜形成，但LTA的具体作用尚不清楚。

在这项研究中，我们证明从植物乳杆菌释放的LTA可以抑制金黄色葡萄球菌生物膜形成和聚集，而不影响金黄色葡萄球菌在各种体外和体内模型中的生长。植物乳杆菌LTA（Lp.LTA）也抑制金黄色葡萄球菌临床分离株（包括甲氧西林抗性株）的生物膜形成。值得注意的是，Lp.LTA不仅干扰金黄色葡萄球菌的生物膜形成，还可破坏了预先形成的生物膜。

机制研究表明，Lp.LTA抑制ica操纵子的表达，该操纵子负责产生金黄色葡萄球菌生物膜发育所需的关键分子聚-N-乙酰葡糖胺。Lp.LTA增加金黄色葡萄球菌自诱导剂-2的释放，有助于抑制金黄色葡萄球菌生物膜形成。此外，Lp.LTA处理增强了生物膜对各种抗生素和巨噬细胞的易感性。有趣的是，没有D-丙氨酸部分的Lp.LTA不能抑制金黄色葡萄球菌的生物膜形成。

总之，该研究表明LTA可抑制金黄色葡萄球菌生物膜形成，因此可用于预防和/或治疗由金黄色葡萄球菌生物膜引起的传染性疾病。

原始出处：

Ahn KB, Baik JE, et al., Lipoteichoic Acid Inhibits Staphylococcus aureus Biofilm Formation. Front Microbiol. 2018 Feb 27;9:327. doi: 10.3389/fmicb.2018.00327. eCollection 2018.

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    2018-09-14 sunylz

    #Bio#

    0

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    2018-11-11 jiafufeng@yaho

    #CRO#

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    2018-08-13 12498ebem31暂无昵称

    #Biol#

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    2019-02-01 xjy02

    #Micro#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1917993, encodeId=4ba1191e993c4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Sep 14 04:01:00 CST 2018, time=2018-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857599, encodeId=51d1185e5997b, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Nov 11 16:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767400, encodeId=44911e674002b, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Aug 13 23:01:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084354, encodeId=472d2084354f8, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Feb 01 02:01:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967141, encodeId=de0b196e141c9, content=<a href='/topic/show?id=d7709560138' target=_blank style='color:#2F92EE;'>#酸抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95601, encryptionId=d7709560138, topicName=酸抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Wed Apr 25 22:01:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305027, encodeId=ed03130502e5f, content=<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96242, encryptionId=4b8896242d4, topicName=金黄色葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Tue Apr 03 12:01:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596894, encodeId=add91596894f1, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Tue Apr 03 12:01:00 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-25 liuyong2980

    #酸抑制#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1917993, encodeId=4ba1191e993c4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Sep 14 04:01:00 CST 2018, time=2018-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857599, encodeId=51d1185e5997b, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Nov 11 16:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767400, encodeId=44911e674002b, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Aug 13 23:01:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084354, encodeId=472d2084354f8, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Feb 01 02:01:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967141, encodeId=de0b196e141c9, content=<a href='/topic/show?id=d7709560138' target=_blank style='color:#2F92EE;'>#酸抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95601, encryptionId=d7709560138, topicName=酸抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Wed Apr 25 22:01:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305027, encodeId=ed03130502e5f, content=<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96242, encryptionId=4b8896242d4, topicName=金黄色葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Tue Apr 03 12:01:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596894, encodeId=add91596894f1, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Tue Apr 03 12:01:00 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-03 jambiya

    #金黄色葡萄球菌#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1917993, encodeId=4ba1191e993c4, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Sep 14 04:01:00 CST 2018, time=2018-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857599, encodeId=51d1185e5997b, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Nov 11 16:01:00 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767400, encodeId=44911e674002b, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Mon Aug 13 23:01:00 CST 2018, time=2018-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084354, encodeId=472d2084354f8, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Feb 01 02:01:00 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967141, encodeId=de0b196e141c9, content=<a href='/topic/show?id=d7709560138' target=_blank style='color:#2F92EE;'>#酸抑制#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95601, encryptionId=d7709560138, topicName=酸抑制)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de89102, createdName=liuyong2980, createdTime=Wed Apr 25 22:01:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305027, encodeId=ed03130502e5f, content=<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96242, encryptionId=4b8896242d4, topicName=金黄色葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Tue Apr 03 12:01:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596894, encodeId=add91596894f1, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Tue Apr 03 12:01:00 CST 2018, time=2018-04-03, status=1, ipAttribution=)]
    2018-04-03 手留余香

    #葡萄球菌#

    0