J Hepatol:全球HBV感染情况分析

2016-09-10 Seven L 译 MedSci原创

背景:关于不同国家的慢性乙型肝炎病毒(HBV)的患病率趋势相关信息是匮乏的;因为我们进行了研究,评估了过去的几十年里,不同国家的慢性HBV感染率变化和变化模式。 方法:根据已发表的慢性HBV的系统回顾数据,我们采用分对数尺度的线性模型,评估特定国家患病率的时间趋势。估计HBsAg阳性率随时间的相对变化情况。 结果:我们获取了50个国家的相关数据,绝大多数显示随着时间的推移,患病率在减少

背景:关于不同国家的慢性乙型肝炎病毒(HBV)的患病率趋势相关信息是匮乏的;因为我们进行了研究,评估了过去的几十年里,不同国家的慢性HBV感染率变化和变化模式。

方法:根据已发表的慢性HBV的系统回顾数据,我们采用分对数尺度的线性模型,评估特定国家患病率的时间趋势。估计HBsAg阳性率随时间的相对变化情况。

结果:我们获取了50个国家的相关数据,绝大多数显示随着时间的推移,患病率在减少。我们对区域内的不同程度异质性进行了观察,地中海东部地区相对同质的模式显示,HBsAg阳性率强烈下降。欧洲显示出混合模式,东部地区的HBsAg阳性率保持稳定较高水平,西部地区则表现出HBsAg阳性率的不断下降。在非洲,一些国家的患病率没有变化;患病率增加的国家有:乌干达(OR 1.05/年,95% CI 1.04-1.06)、尼日利亚(1.02; 1.02-1.02)、塞内加尔(1.01; 1.01-1.02)和南非(1.02; 1.01-1.02)。东南亚和西太平洋地区的国家其变化模式存在重叠,以低中HBsAg的下降为特点,在中国和马来西亚最为突出。

结论:大多数国家的HBsAg阳性率在下降。即使在区域内,HBsAg阳性率也存在动态变化;患病率的下降可能是儿童接种疫苗所致。不过对于HBsAg阳性率仍保持较高水平的非洲和东欧的一些国家,可能需要采取进一步预防措施。

原始出处:

Jördis J Ott.et al.Time trends of chronic HBV infection over prior decades – a global analysis.J Hepatol.Published online: August 31, 2016

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    2017-01-10 klivis
  2. 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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

  3. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 23:03:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-23 1e10c84am36(暂无匿称)

    文章不错,继续学习

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 23:03:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-23 1e10c84am36(暂无匿称)

    文章不错,继续学习

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 23:03:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-17 忠诚向上

    好好学习一下

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 23:03:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-14 青龙偃月

    学习了,赞一个!

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 23:03:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-14 吴教授

    乙肝病人会越来越少的

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 23:03:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-14 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!!

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 23:03:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 doctorJiangchao

    继续学习

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Sep 13 23:03:00 CST 2016, time=2016-09-13, status=1, ipAttribution=)]
    2016-09-13 doctorJiangchao

    好文章

    0

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