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Cancer Prev Res：桂皮提取物可抑癌

2015-06-17 王英 生物通

桂皮直肠癌Nrf2拮抗剂
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结直肠癌的渐进性和较差预后，与疾病的转移性阶段有关，迫切需要开发更有效的治疗策略。越来越多的证据表明，氧化还原反应敏感性转录因子Nrf2是细胞抗氧化防御的主调节因子，从而是结直肠癌化学预防的一种很有前途的分子靶标。最近，美国亚利桑那大学（UA）药学院和UA癌症中心研究人员进行的一项研究表明，肉桂（Cinnamomum aromaticum和Cinnamomum verum）的树皮——桂皮，是Nrf

结直肠癌的渐进性和较差预后，与疾病的转移性阶段有关，迫切需要开发更有效的治疗策略。越来越多的证据表明，氧化还原反应敏感性转录因子Nrf2是细胞抗氧化防御的主调节因子，从而是结直肠癌化学预防的一种很有前途的分子靶标。

最近，美国亚利桑那大学（UA）药学院和UA癌症中心研究人员进行的一项研究表明，肉桂（Cinnamomum aromaticum和Cinnamomum verum）的树皮——桂皮，是Nrf2诱导物肉桂醛（cinnamaldehyde，给予桂皮独特风味和香味的化合物，可在人类上皮结肠细胞中诱发Nrf2调控的抗氧化反应）丰富的饮食来源，从而将桂皮的这种成分确定为一种有效的结直肠癌抑制剂。

本文共同通讯作者分别是副教授Georg Wondrak博士和Donna Zhang教授，他们都来自于UA药理学与毒理学药科学院，他们最近完成的一项研究证明，在小鼠饮食中加入肉桂醛，可以保护小鼠抵御结直肠癌。动物的细胞对肉桂醛产生反应，会获得一种能力，通过解毒和修复，保护自己免于暴露致癌物。

Donna Zhang教授现就职于美国亚利桑那大学药学院，是2012年美国药理毒理学会（SOT）成就奖获得者，近十年来致力于Nrf2-Keap1-ARE信号通路的研究。经过多年的探索，她的团队从天然植物中提取到了目前证实有效的唯一的一种天然Nrf2拮抗剂（Brusatol），有望缓解肿瘤的耐药问题。相关研究成果连续在SCI期刊上发表近50篇论文，并获得多个美国国立卫生研究院R01课题资助。

Zhang教授表示：“这是一个重大发现。因为结直肠癌是侵袭性的，并且预后不良，迫切需要开发更有效的策略来对抗对这种疾病。”Wondrak补充说：“鉴于桂皮作为世界上第三大消费香料的重要地位，对其潜在的健康益处，我们还研究相对较少。如果我们可以确定桂皮的积极作用，我们就可以利用这个机会，改善世界人民的健康。”

Wondrak博士和Zhang教授的这项研究，以“'Nrf2-dependent suppression of azoxymethane/dextrane sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde”为题，在线发表于最近的国际期刊Cancer Prevention Research。

该研究小组接下来准备测试的是，是否桂皮——与肉桂醛完全不同，可使用相同的肿瘤模型预防癌症。因为桂皮是一种常见的食品添加剂，已经被确认为是安全的，它不是一种合成的新药物，因此在人类中开展研究可能并不太遥远。

Wondrak概述了该研究会继续探索的问题：“现在我们知道提炼的肉桂醛可以抑制结直肠癌，那么桂皮有这个效果吗？是否我们可以使用肉桂醛和桂皮作为武器，来预防其他重大疾病，如炎症失调和糖尿病？这些都是大问题，使用一种非常常见的香料，我们能为这些问题提供令人鼓舞的答案。”

原始出处：

Long M, Tao S, Rojo de la Vega M, Jiang T，et al.Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.Cancer Prev Res (Phila). 2015 May;8(5):444-54. doi: 10.1158/1940-6207.CAPR-14-0359. Epub 2015 Feb 23.

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    2016-11-19 小康子70

    有看到它对真菌也有作用，无处不在，哈哈

    0

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    2015-08-25 jingyanzhu715_39486108

    #抑癌#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=156945, encodeId=b52615694508, content=有看到它对真菌也有作用，无处不在，哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Sat Nov 19 23:50:43 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640644, encodeId=21691640644cf, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Tue Aug 25 15:28:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31796, encodeId=b1af31e968a, content=中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e52e84884, createdName=lxm5668, createdTime=Thu Jul 09 10:56:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29235, encodeId=d6c02923502, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:07:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28555, encodeId=69bc28555a8, content=很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bae01627531, createdName=erhong, createdTime=Sun Jun 21 20:21:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28527, encodeId=5feb2852ebd, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28530, encodeId=98ea2853014, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28529, encodeId=f18d28529e4, content=！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28528, encodeId=0ec328528f1, content=貌似很厉害的样子, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28526, encodeId=cab22852618, content=中医有待发扬, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=)]
    2015-07-09 lxm5668

    中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=156945, encodeId=b52615694508, content=有看到它对真菌也有作用，无处不在，哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Sat Nov 19 23:50:43 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640644, encodeId=21691640644cf, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Tue Aug 25 15:28:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31796, encodeId=b1af31e968a, content=中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e52e84884, createdName=lxm5668, createdTime=Thu Jul 09 10:56:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29235, encodeId=d6c02923502, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:07:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28555, encodeId=69bc28555a8, content=很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bae01627531, createdName=erhong, createdTime=Sun Jun 21 20:21:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28527, encodeId=5feb2852ebd, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28530, encodeId=98ea2853014, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28529, encodeId=f18d28529e4, content=！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28528, encodeId=0ec328528f1, content=貌似很厉害的样子, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28526, encodeId=cab22852618, content=中医有待发扬, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=)]
    2015-06-25 huaxipanxing

    看看

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=156945, encodeId=b52615694508, content=有看到它对真菌也有作用，无处不在，哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Sat Nov 19 23:50:43 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640644, encodeId=21691640644cf, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Tue Aug 25 15:28:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31796, encodeId=b1af31e968a, content=中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e52e84884, createdName=lxm5668, createdTime=Thu Jul 09 10:56:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29235, encodeId=d6c02923502, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:07:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28555, encodeId=69bc28555a8, content=很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bae01627531, createdName=erhong, createdTime=Sun Jun 21 20:21:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28527, encodeId=5feb2852ebd, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28530, encodeId=98ea2853014, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28529, encodeId=f18d28529e4, content=！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28528, encodeId=0ec328528f1, content=貌似很厉害的样子, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28526, encodeId=cab22852618, content=中医有待发扬, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=)]
    2015-06-21 erhong

    很厉害

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=156945, encodeId=b52615694508, content=有看到它对真菌也有作用，无处不在，哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Sat Nov 19 23:50:43 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640644, encodeId=21691640644cf, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Tue Aug 25 15:28:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31796, encodeId=b1af31e968a, content=中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e52e84884, createdName=lxm5668, createdTime=Thu Jul 09 10:56:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29235, encodeId=d6c02923502, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:07:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28555, encodeId=69bc28555a8, content=很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bae01627531, createdName=erhong, createdTime=Sun Jun 21 20:21:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28527, encodeId=5feb2852ebd, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28530, encodeId=98ea2853014, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28529, encodeId=f18d28529e4, content=！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28528, encodeId=0ec328528f1, content=貌似很厉害的样子, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28526, encodeId=cab22852618, content=中医有待发扬, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=)]
    2015-06-21 18619c0a62m

    (⊙o⊙)

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=156945, encodeId=b52615694508, content=有看到它对真菌也有作用，无处不在，哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Sat Nov 19 23:50:43 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640644, encodeId=21691640644cf, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Tue Aug 25 15:28:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31796, encodeId=b1af31e968a, content=中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e52e84884, createdName=lxm5668, createdTime=Thu Jul 09 10:56:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29235, encodeId=d6c02923502, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:07:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28555, encodeId=69bc28555a8, content=很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bae01627531, createdName=erhong, createdTime=Sun Jun 21 20:21:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28527, encodeId=5feb2852ebd, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28530, encodeId=98ea2853014, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28529, encodeId=f18d28529e4, content=！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28528, encodeId=0ec328528f1, content=貌似很厉害的样子, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28526, encodeId=cab22852618, content=中医有待发扬, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=)]
    2015-06-21 18619c0a62m

    。。。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=156945, encodeId=b52615694508, content=有看到它对真菌也有作用，无处不在，哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Sat Nov 19 23:50:43 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640644, encodeId=21691640644cf, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Tue Aug 25 15:28:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31796, encodeId=b1af31e968a, content=中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e52e84884, createdName=lxm5668, createdTime=Thu Jul 09 10:56:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29235, encodeId=d6c02923502, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:07:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28555, encodeId=69bc28555a8, content=很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bae01627531, createdName=erhong, createdTime=Sun Jun 21 20:21:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28527, encodeId=5feb2852ebd, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28530, encodeId=98ea2853014, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28529, encodeId=f18d28529e4, content=！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28528, encodeId=0ec328528f1, content=貌似很厉害的样子, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28526, encodeId=cab22852618, content=中医有待发扬, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=)]
    2015-06-21 18619c0a62m

    ！！！

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=156945, encodeId=b52615694508, content=有看到它对真菌也有作用，无处不在，哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Sat Nov 19 23:50:43 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640644, encodeId=21691640644cf, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Tue Aug 25 15:28:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31796, encodeId=b1af31e968a, content=中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e52e84884, createdName=lxm5668, createdTime=Thu Jul 09 10:56:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29235, encodeId=d6c02923502, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:07:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28555, encodeId=69bc28555a8, content=很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bae01627531, createdName=erhong, createdTime=Sun Jun 21 20:21:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28527, encodeId=5feb2852ebd, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28530, encodeId=98ea2853014, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28529, encodeId=f18d28529e4, content=！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28528, encodeId=0ec328528f1, content=貌似很厉害的样子, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28526, encodeId=cab22852618, content=中医有待发扬, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=)]
    2015-06-21 18619c0a62m

    貌似很厉害的样子

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=156945, encodeId=b52615694508, content=有看到它对真菌也有作用，无处不在，哈哈, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83ep3KyYH7kyqVwUwK81ibQRkWMqRMVwerlwD2Ie9byeRp2RL9wKmLgoNwShDTdTNL8RQHfhDsAt0N9A/132, createdBy=99b61684657, createdName=小康子70, createdTime=Sat Nov 19 23:50:43 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640644, encodeId=21691640644cf, content=<a href='/topic/show?id=fd575494e5e' target=_blank style='color:#2F92EE;'>#抑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54947, encryptionId=fd575494e5e, topicName=抑癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=35f822706827, createdName=jingyanzhu715_39486108, createdTime=Tue Aug 25 15:28:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31796, encodeId=b1af31e968a, content=中成药右归胶囊中就有肉桂的成分，右归胶囊也有增加免疫力的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e52e84884, createdName=lxm5668, createdTime=Thu Jul 09 10:56:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29235, encodeId=d6c02923502, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Thu Jun 25 23:07:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28555, encodeId=69bc28555a8, content=很厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bae01627531, createdName=erhong, createdTime=Sun Jun 21 20:21:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28527, encodeId=5feb2852ebd, content=(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28530, encodeId=98ea2853014, content=。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28529, encodeId=f18d28529e4, content=！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28528, encodeId=0ec328528f1, content=貌似很厉害的样子, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28526, encodeId=cab22852618, content=中医有待发扬, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12a31627589, createdName=18619c0a62m, createdTime=Sun Jun 21 16:54:00 CST 2015, time=2015-06-21, status=1, ipAttribution=)]
    2015-06-21 18619c0a62m

    中医有待发扬

    0

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